Application Information

This drug has been submitted to the FDA under the reference 020152/001.

Names and composition

"SERZONE" is the commercial name of a drug composed of NEFAZODONE HYDROCHLORIDE.

Forms

ApplId/ProductId Drug name Active ingredient Form Strenght
020152/001 SERZONE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 50MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
020152/002 SERZONE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 100MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
020152/003 SERZONE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 150MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
020152/004 SERZONE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 200MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
020152/005 SERZONE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 250MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
020152/006 SERZONE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 300MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**

Similar Active Ingredient

ApplId/ProductId Drug name Active ingredient Form Strenght
020152/001 SERZONE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 50MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
020152/002 SERZONE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 100MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
020152/003 SERZONE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 150MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
020152/004 SERZONE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 200MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
020152/005 SERZONE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 250MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
020152/006 SERZONE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 300MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
075763/001 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 50MG
075763/002 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 100MG
075763/003 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 150MG
075763/004 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 200MG
075763/005 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 250MG
076037/001 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 50MG
076037/002 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 100MG
076037/003 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 150MG
076037/004 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 200MG
076037/005 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 250MG
076072/001 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 50MG
076072/002 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 100MG
076072/003 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 150MG
076072/004 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 200MG
076072/005 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 250MG
076073/002 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 100MG
076073/003 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 150MG
076073/004 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 200MG
076073/005 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 250MG
076129/002 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 100MG
076129/003 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 150MG
076129/004 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 200MG
076129/005 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 250MG
076196/001 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 50MG
076196/002 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 100MG
076196/003 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 150MG
076196/004 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 200MG
076196/005 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 250MG
076302/001 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 50MG
076302/002 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 100MG
076302/003 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 150MG
076302/004 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 200MG
076302/005 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 250MG
076309/001 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 50MG
076309/002 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 100MG
076309/003 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 150MG
076309/004 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 200MG
076309/005 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 250MG
076409/001 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 50MG
076409/002 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 100MG
076409/003 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 150MG
076409/004 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 200MG
076409/005 NEFAZODONE HYDROCHLORIDE NEFAZODONE HYDROCHLORIDE TABLET/ORAL 250MG

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Answered questions

Has anyone heard of serzone?
I was just reading that it is better for people to take than sarafem. It also has no sexual side effects. Asked by Teddy Sablea 2 years ago.

Frequently Asked Questions What is nefazodone (Serzone)? Nefazodone (Serzone) is a new antidepressant with a chemical structure that is somewhat similar to that of the phenylpiperazine antidepressant, trazodone (Desyrel). The antidepressant action of nefazodone is thought to be dependent on its ability to block postsynaptic serotonin type-2 receptors and inhibit presynaptic serotonin reuptake. Nefazodone also blocks norepinephrine reuptake. Nefazodone does not have a chemical structure similar to the SSRIs, tricyclic antidepressants, monoamine oxidase inhibitors, bupropion, or venlafaxine. How does nefazodone differ from other antidepressants? One possibly important way in which nefazodone differs from other SSRIs is that while use of SSRIs is often associated with sexual dysfunction and sleep disturbances, these side-effects have been reported infrequently in people taking nefazodone. What kinds of depression can be treated with nefazodone? While the pre-marketing studies were restricted to patients with a DSM-III-R diagnosis of non-melancholic Major Depressive Disorder, it is expected that nefazodone will be prescribed for patients with Dysthymia, Major Depression, and Bipolar Disorder. Although nefazodone has mostly been studied for periods of administration of up to 8 weeks, it is expected that patients with long-standing depressions will take the drug for longer periods of time. Data on about 250 patients who took nefazodone for 12 or more months did not reveal any problems with administration for that length of time. As yet, there is no data on the effectiveness of nefazodone when used to treat patients whose depressions were so severe as to make hospitalization necessary. What are the side-effects of nefazodone? The side-effects that occurred significantly more commonly in people taking nefazodone as compared to placebo are: Side-effect Patients Dry mouth 25% Sleepiness/sedation 25% Nausea 22% Dizziness 17% Visual problems 16% Weakness 11% Lightheadedness 10% Confusion 7% Orthostatic hypotension 5% Note: The Psychopharmacology Forum of InterPsych has received one report of inappropriate erections in a patient taking nefazodone. It is expected that priapism will be reported shortly as inappropriate erections and priapism are often associated. Which side-effects force people to stop taking nefazodone? In the premarketing studies 16% of the 3496 depressed patients taking nefazodone discontinued the medication because of side-effects. The side-effects that the patients cited as the reason they dropped out that were mentioned at least twice as often for nefazodone as compared to placebo are: Side-effect Patients Nausea 3.5% Dizziness 1.9% Insomnia 1.5% Weakness 1.3% Agitation 1.2% Are there any special hazards for people with bipolar disorder? As with other antidepressants, people with bipolar disorder who are not being treated with a mood regulator such as lithium, valproate (Depakote), or carbamazepine (Tegretol) may be pushed into a manic episode when treated with nefazodone. In the pre-marketing studies, the rate of manic episodes in patients with bipolar disorder was 1.6%. Does nefazodone interact with other medications? Nefazodone increases the blood level of Seldane and Hismanal to possibly life-threatening levels. These antihistamines should never be taken while taking nefazodone. The blood levels of Halcion and Xanax are also increased by nefazodone. If Halcion is taken with nefazodone, its dose should be reduced by 75%. A reduction of 50% in the dose of Xanax is suggested if it is taken with nefazodone. Does nefazodone interact with alcohol? Although nefazodone has not been found to increase the impairment of cognitive or motor skills caused by alcohol, the manufacturer warns against drinking while taking nefazodone. Is nefazodone safe for a woman who is pregnant, about to become pregnant, or nursing an infant? There is no data to establish the safety of nefazodone for the fetus or nursing infant. Is nefazodone a satisfactory antidepressant for children and adolescents? Although there have been no published studies on the use of nefazodone for the treatment of children and adolescents with depression, it is expected that the drug will be prescribed for depressed children and adolescents. Is nefazodone a satisfactory antidepressant for the elderly? No special problems were encountered when nefazodone was studied in a group of 500 people over the age of 65 with depression. As with most drugs, when administered to the elderly, it is useful to start low and go slow. How is treatment with nefazodone initiated? Most psychiatrists start people with depression on 50 mg of nefazodone twice a day. At intervals of about one week, the dose can be increased by 100 mg per day. When nefazodone first was released the usual starting dose for adults was 100 mg twice a day. As many people found this dose to be too high, it has been replaced by a lower initial dose. When nefazodone is given to elderly patients the starting dose is usually 50 mg twice a day. What is the usual final dose of nefazodone? While doses up to 600 mg per day are approved by the FDA, some severely depressed patients have been treated with higher doses. Most depressed people respond to doses under 600 mg per day. How long does it take nefazodone to relieve depression? While most people taking nefazodone become aware of some lessening of depression within two to four weeks, there are some who experience relief within the first week and others who only experience relief after many weeks of therapy. Are there withdrawal effects if nefazodone is suddenly discontinued? A withdrawal syndrome following the abrupt discontinuation of nefazodone has not been described. Because the half-lives of nefazodone and its active metabolites are 18 hours or less, it is prudent to taper nefazodone rather than abruptly discontinue it. Is nefazodone toxic if an overdose is taken? Seven overdoses of nefazodone have been reported. The highest reported overdose was 11,200 mg. In some cases nefazodone was taken along with alcohol and/or other medications. All seven people who took an overdose recovered. What precautions are necessary when switching between nefazodone and an MAO inhibitor? When switching from an MAO inhibitor to nefazodone, there should be a 14-day interval between the discontinuation of the MAOI and the initiation of nefazodone therapy. When switching from nefazodone to an MAOI, a 7-day interval is adequate, because of nefazodone's short half-life. What does nefazodone cost? Nefazodone is supplied in tablets ranging from 100 mg to 250 mg in strength. The 100 mg tablets cost pharmacies nearly as much as the 250 mg tablets. It is expected that all strengths of nefazodone will be sold for between $0.80 and $1.25 per tablet. Might nefazodone be effective when a person has not responded to other antidepressants? Although there is no data on this, it is expected that some individuals who have failed to be helped by other antidepressants will be helped by nefazodone. What are the advantages of nefazodone? The low incidence of sexual side-effects and disturbed sleep are possible advantages of nefazodone. Has nefazodone been available in other countries? What do psychopharmacologists from those countries think of the drug? Nefazodone has been available in Canada for over six months. Most of the psychopharmacologists to whom I have spoken think that it is less effective than the SSRIs, and some have stopped writing prescriptions for it. Most of the nefazodone being prescribed in Canada is prescribed by nonpsychiatric physicians, not by psychiatrists. What did the Medical Letter conclude about nefazodone? The Medical Letter [1995, 37 (946), 33-35] concluded its review of nefazodone with the words: "Available data are inadequate to determine how nefazodone compares Answered by Rebecka Dischner 2 years ago.

The most important thing to know here is that this drug was pulled off the market in Canada in 2003 and pulled from the US market in 2004 (although the generic form is still available-nefazadone) due to deaths resulting from liver failure directly associated with the drug. The significant danger, despite this side effect being rare, is that it is unpredictable and happens without warning, necessitating a liver transplant. There are much safer and effective anti-depressants available and if the sexual side effects are what concern you, try wellbutrin along with prozac (same as sarafem) as it can usually combat those side effects. Answered by Phung Simley 2 years ago.

Depression is everywhere, some brains are just wired better to cope. This is why all of the drug companies are formulating anti-depressants. My sister in law, my husband's co-worker, my mother, my grandfather, my best friends mother (who ended up going back to school and getting her doctorate in psychology to help others with depression) - all had different paths to try and deal with this. None were short. At least today it's acceptable as a legitimate illness and not looked down upon. This is why Brooke Shields wrote a book on post partum depression. There are a gazillion medications, some take awhile to work, sometimes you need a change. Please don't finish the job. If things aren't changing then you need to change your counselor, doctor and perhaps meds. Some meds can cause depression and suicidal thoughts to increase - which is why the warning labels always say to call your doc immediately if you have these thoughts. Don't feel guilty about leaving your counselor to go to another. A diploma on the wall doesn't mean they graduated with all "A's"! Are you working? If not you need to fill your time with something productive that makes you feel worthwhile. If you come really close to finishing the job, call your local crisis hotline, go to the ER. It would be best if you are not alone during this time of stabilizing on the meds. And if your insurance covers it, there is absolutely not shame in asking to be admitted to an inpatient unit where they can monitor you and your meds. My grandfather and best friends mom both went the inpatient route, as did my husband's co-worker. My sister in law had daily intensive therapy and 2 or 3 medication changes and my mother had therapy several times a week along with medication. It can be conquered! Answered by Ayesha Mittelstaedt 2 years ago.

Sarafem, the other drug you mention, is Prozac. It's been marketed under the name Sarafem in the US for women who have severe PMS but who might not want an antidepressant - bit of a crafty marketing ploy, and bit deceptive... Answered by Wendell Kaub 2 years ago.

My husband took it for about 6 months. He had a lot of weight gain so he quit. He now takes Lamictal with no side effects whatsoever. Best wishes! Answered by Narcisa Lust 2 years ago.

Serzone was an antidepressant that I took. It was taken off the market a few years ago in the U.S. when a few people in Europe died from liver failure. It worked very good for me. Answered by Elodia Feeling 2 years ago.

Yes, it is an antidepressant medication. What would you like to know about it specifically? Answered by Tracie Lifton 2 years ago.

i have never heard of it. is it some kind of sickness or something??? Answered by Jadwiga Aarsvold 2 years ago.

ummmmmmm no i have no idea Answered by Evan Leininger 2 years ago.


Anyone familiar with Ativan? How about Serzone?
I took Serzone for about 6 years and through a series of insurance problems, ended up off the Serzone and on Ativan. I've been taking "about" 2 mg. of Ativan a day for the last 1 1/2 years. ( 1/2 mg 3 times a day - 4 times max)Anyway, I made an attempt at cutting down on the Ativan yesterday by... Asked by Robbi Frein 2 years ago.

I took Serzone for about 6 years and through a series of insurance problems, ended up off the Serzone and on Ativan. I've been taking "about" 2 mg. of Ativan a day for the last 1 1/2 years. ( 1/2 mg 3 times a day - 4 times max) Anyway, I made an attempt at cutting down on the Ativan yesterday by not taking a dose at bedtime. I woke up this morning about 3 am and just sort of layed in bed. When I got up around 6 am, I felt very strange. I just felt like crying. And I did. I took 1/2 mg dose and by 7 am I felt much better. Question: Is getting off the Ativan going to be a really bad experience? I don't want to go off my nut but I'd really like to cut the dose back. Could starting the Serzone again make it easier? Emails are welcome. Just go to my profile to email me. Thanks. Answered by Marisela Macgowan 2 years ago.


Has anyone tried Serzone (Nefazodone)?
I was really looking for someone who has tried this stuff, thanks for the info though. I am aware that it can cause fatal liver failure. Asked by Jesusita Beckor 2 years ago.

I took Serzone for 3 years. I worked great. I was not able to handle the side affects of the other designer drugs like prozac or zoloft...etc. I took 2 mg of colonapin at Night for sleep and the combo worked great. My Dr. had me take a simple liver function test every six months because the med was causing some problems with liver damage (including statistically significant deaths) I stopped taking the med after I lost my health insurance. No other Dr. will per scribe it now because it is on th e"black list" I would still take it as long as I took the liver function tests periodically. Good Luck Answered by Darcie Haugen 2 years ago.

Serzone sucks Answered by Naoma Griffin 2 years ago.


Has anyone heard of serzone?
Asked by Britta Peskind 2 years ago.

What is Serzone? • Serzone is an antidepressant medication. It affects chemicals in the brain that may become unbalanced and cause depression. • Serzone is used to relieve symptoms of depression such as feelings of sadness, worthlessness, or guilt; loss of interest in daily activities; changes in appetite; tiredness; sleeping too much; insomnia; and thoughts of death or suicide. Answered by Felecia Gorn 2 years ago.

The most important thing to know here is that this drug was pulled off the market in Canada in 2003 and pulled from the US market in 2004 (although the generic form is still available-nefazadone) due to deaths resulting from liver failure directly associated with the drug. The significant danger, despite this side effect being rare, is that it is unpredictable and happens without warning, necessitating a liver transplant. There are much safer and effective anti-depressants available and if the sexual side effects are what concern you, try wellbutrin along with prozac (same as sarafem) as it can usually combat those side effects. Answered by Donya Farmer 2 years ago.


Serzone(nefazodone) or prozac is better?
i have to start anti depressant which works more both of them can any body tell me Asked by Bettie Toomey 2 years ago.

Serzone is better and here is why: It works on two brain chemicals rather than only one like Prozac Nefazodone's claimed advantages over other antidepressants include reduced possibility of disturbed sleep or sexual dysfunction, and ability to treat some patients who did not respond to other antidepressant drugs. Answered by Margrett Zirkles 2 years ago.


Who used to take the antidepressant Serzone that they took off the market? What medicine are you using now?
I took Serzone for a couple years in the 90s & it helped. I need a medication similiar to it. I cannot tolerate Zoloft or Paxil. Asked by Joie Pinales 2 years ago.

The company that made the "brand" named "Serzone" stopped making it. It was not taken off the market. There is a company named, TEVA, that still makes and sells nefazadone, which is the medicine that Serzone is the brand of. I know because I've taken that medication for years and still take it. Hope that helps. Answered by Lavonia Mabe 2 years ago.

Never took Serzone...Am on no medication for depression at present...All drugs legal or otherwise do is "mask the real problem"...Get busy, try doing for others, that will knock the "oh poor me" right out of you fast & there are no ugly side effects! Answered by Diedre Glodowski 2 years ago.

I heard Effexor works wonders & helps with weight loss! you could use as low as a 37.5 mg dose Answered by Phuong Mable 2 years ago.

I did, messed with my head. Now I take Cymbalta works great. Answered by Steven Dzuro 2 years ago.


Can Serzone be combined with Cymbalta?
My doc was looking into this when his computer went down. The cymbalta is best for pain, but the Serzone is best for depression for me. I really want to take them together. Serzone=Nefazadone Asked by Whitney Englemann 2 years ago.

duloxetine (cymbalta) and nefazadone (serzone) should NEVER be mixed. infact duloxetine should NEVER be mixed with any anti-depressants! the combined effects on the chemicals produced by the brain is catastrophic! it can cause permanent liver damage and increase risk of suicide. DO NOT TAKE THESE MEDS TOGETHER. consult your MD about other options, preferably a different one then prescribed you these drugs together in the fist place. good luck Answered by Linda Aloisi 2 years ago.


SerZone (nefazodone)?
Hi there,I have been wanting to titrate off nefazodone for years. Does anyone have experience with the withdrawal from this medication?I have been taking 600 mg (divided doses) q day.What can I expect? Any known cases of death from withdrawal?Is it better to do it on an impatient basis?I took it for... Asked by Joselyn Nunz 2 years ago.

Hi there, I have been wanting to titrate off nefazodone for years. Does anyone have experience with the withdrawal from this medication? I have been taking 600 mg (divided doses) q day. What can I expect? Any known cases of death from withdrawal? Is it better to do it on an impatient basis? I took it for severe panic attacks. I am worried that the attacks will return BIGTIME. Any and all information will be helpful. Thanks, Christine Answered by Tamie Harritt 2 years ago.

I do not know that medecine, but I went cold turkey on mine (paraxotine), and that was a terrible mistake. I felt so bad for long time after and was too stubborn to go back on. Whatever meds you're on, you should NOT stop/reduce them without doctor's advice! for your own sake! Answered by Salina Akapo 2 years ago.

I have been taking Serzone for many years and am currently titrating off this drug. The process should take about six months with a 50 mg decrease every 6-8 weeks. I am experiencing some anxiety but it is manageable. Please don't try to go off without titration. JHM Answered by Douglas Boyas 2 years ago.


Has anyone ever taken serzone and/or cymblata?
I have been on Serzone for 7 years and just started having severe side effects and my doctor is weaning me off and starting me on cymbalta. Getting off the serzone is HELL!!!! Just wanted to know if anyone has had a similar instance.....and does Cymbalta work for anyone? Asked by Gaye Marseilles 2 years ago.

Yes I am on cymbalta! I've been on it 6 months. I have no side effects from it. It has helped me out. I was put on it for chronic pain. I still have pain but not like I used too. It has been a big relief to not have so much pain in my body and joints. Hugs! Answered by Deandrea Tetu 2 years ago.

Tried the cymbalta, didnt like the side effects and stopped after 6 weeks. I thought it helped a little, very little but not worth taking for a long time. I heard it was hard to get off of it. Answered by Elfreda Norlund 2 years ago.

I am taking Cymbalta and it has worked well for me. It's like Serzone as far as getting off of it, but I haven't suffered any side effects from it. I'd suggest that you try it. Answered by Natisha Loe 2 years ago.

I ended up in the hospital becasue of the side effects of Cymbalta.. BUT.. not everyone has the same side effects from every med Everyone is unique Answered by Katie Yurchiak 2 years ago.


Can nefazodone (Serzone) be taken while a woman is pregnant?
Asked by Emil Lehneis 2 years ago.

It´s not advised to take it during pregnancy. It might cause a miscarriage or deformities. I would discuss this issue with a doctor not on yahoo answers !!! Answered by Kym Luebbe 2 years ago.

Would definitely talk to your doctor about this as birth defects and malformities are highly probable Answered by Yevette Joun 2 years ago.

No! You should seek advice from your OBGYN. Answered by Cathleen Ehman 2 years ago.


Has anyone heard of serzone?
I was just reading that it is better for people to take than sarafem. It also has no sexual side effects. Asked by Rufus Vejar 2 years ago.

Frequently Asked Questions What is nefazodone (Serzone)? Nefazodone (Serzone) is a new antidepressant with a chemical structure that is somewhat similar to that of the phenylpiperazine antidepressant, trazodone (Desyrel). The antidepressant action of nefazodone is thought to be dependent on its ability to block postsynaptic serotonin type-2 receptors and inhibit presynaptic serotonin reuptake. Nefazodone also blocks norepinephrine reuptake. Nefazodone does not have a chemical structure similar to the SSRIs, tricyclic antidepressants, monoamine oxidase inhibitors, bupropion, or venlafaxine. How does nefazodone differ from other antidepressants? One possibly important way in which nefazodone differs from other SSRIs is that while use of SSRIs is often associated with sexual dysfunction and sleep disturbances, these side-effects have been reported infrequently in people taking nefazodone. What kinds of depression can be treated with nefazodone? While the pre-marketing studies were restricted to patients with a DSM-III-R diagnosis of non-melancholic Major Depressive Disorder, it is expected that nefazodone will be prescribed for patients with Dysthymia, Major Depression, and Bipolar Disorder. Although nefazodone has mostly been studied for periods of administration of up to 8 weeks, it is expected that patients with long-standing depressions will take the drug for longer periods of time. Data on about 250 patients who took nefazodone for 12 or more months did not reveal any problems with administration for that length of time. As yet, there is no data on the effectiveness of nefazodone when used to treat patients whose depressions were so severe as to make hospitalization necessary. What are the side-effects of nefazodone? The side-effects that occurred significantly more commonly in people taking nefazodone as compared to placebo are: Side-effect Patients Dry mouth 25% Sleepiness/sedation 25% Nausea 22% Dizziness 17% Visual problems 16% Weakness 11% Lightheadedness 10% Confusion 7% Orthostatic hypotension 5% Note: The Psychopharmacology Forum of InterPsych has received one report of inappropriate erections in a patient taking nefazodone. It is expected that priapism will be reported shortly as inappropriate erections and priapism are often associated. Which side-effects force people to stop taking nefazodone? In the premarketing studies 16% of the 3496 depressed patients taking nefazodone discontinued the medication because of side-effects. The side-effects that the patients cited as the reason they dropped out that were mentioned at least twice as often for nefazodone as compared to placebo are: Side-effect Patients Nausea 3.5% Dizziness 1.9% Insomnia 1.5% Weakness 1.3% Agitation 1.2% Are there any special hazards for people with bipolar disorder? As with other antidepressants, people with bipolar disorder who are not being treated with a mood regulator such as lithium, valproate (Depakote), or carbamazepine (Tegretol) may be pushed into a manic episode when treated with nefazodone. In the pre-marketing studies, the rate of manic episodes in patients with bipolar disorder was 1.6%. Does nefazodone interact with other medications? Nefazodone increases the blood level of Seldane and Hismanal to possibly life-threatening levels. These antihistamines should never be taken while taking nefazodone. The blood levels of Halcion and Xanax are also increased by nefazodone. If Halcion is taken with nefazodone, its dose should be reduced by 75%. A reduction of 50% in the dose of Xanax is suggested if it is taken with nefazodone. Does nefazodone interact with alcohol? Although nefazodone has not been found to increase the impairment of cognitive or motor skills caused by alcohol, the manufacturer warns against drinking while taking nefazodone. Is nefazodone safe for a woman who is pregnant, about to become pregnant, or nursing an infant? There is no data to establish the safety of nefazodone for the fetus or nursing infant. Is nefazodone a satisfactory antidepressant for children and adolescents? Although there have been no published studies on the use of nefazodone for the treatment of children and adolescents with depression, it is expected that the drug will be prescribed for depressed children and adolescents. Is nefazodone a satisfactory antidepressant for the elderly? No special problems were encountered when nefazodone was studied in a group of 500 people over the age of 65 with depression. As with most drugs, when administered to the elderly, it is useful to start low and go slow. How is treatment with nefazodone initiated? Most psychiatrists start people with depression on 50 mg of nefazodone twice a day. At intervals of about one week, the dose can be increased by 100 mg per day. When nefazodone first was released the usual starting dose for adults was 100 mg twice a day. As many people found this dose to be too high, it has been replaced by a lower initial dose. When nefazodone is given to elderly patients the starting dose is usually 50 mg twice a day. What is the usual final dose of nefazodone? While doses up to 600 mg per day are approved by the FDA, some severely depressed patients have been treated with higher doses. Most depressed people respond to doses under 600 mg per day. How long does it take nefazodone to relieve depression? While most people taking nefazodone become aware of some lessening of depression within two to four weeks, there are some who experience relief within the first week and others who only experience relief after many weeks of therapy. Are there withdrawal effects if nefazodone is suddenly discontinued? A withdrawal syndrome following the abrupt discontinuation of nefazodone has not been described. Because the half-lives of nefazodone and its active metabolites are 18 hours or less, it is prudent to taper nefazodone rather than abruptly discontinue it. Is nefazodone toxic if an overdose is taken? Seven overdoses of nefazodone have been reported. The highest reported overdose was 11,200 mg. In some cases nefazodone was taken along with alcohol and/or other medications. All seven people who took an overdose recovered. What precautions are necessary when switching between nefazodone and an MAO inhibitor? When switching from an MAO inhibitor to nefazodone, there should be a 14-day interval between the discontinuation of the MAOI and the initiation of nefazodone therapy. When switching from nefazodone to an MAOI, a 7-day interval is adequate, because of nefazodone's short half-life. What does nefazodone cost? Nefazodone is supplied in tablets ranging from 100 mg to 250 mg in strength. The 100 mg tablets cost pharmacies nearly as much as the 250 mg tablets. It is expected that all strengths of nefazodone will be sold for between $0.80 and $1.25 per tablet. Might nefazodone be effective when a person has not responded to other antidepressants? Although there is no data on this, it is expected that some individuals who have failed to be helped by other antidepressants will be helped by nefazodone. What are the advantages of nefazodone? The low incidence of sexual side-effects and disturbed sleep are possible advantages of nefazodone. Has nefazodone been available in other countries? What do psychopharmacologists from those countries think of the drug? Nefazodone has been available in Canada for over six months. Most of the psychopharmacologists to whom I have spoken think that it is less effective than the SSRIs, and some have stopped writing prescriptions for it. Most of the nefazodone being prescribed in Canada is prescribed by nonpsychiatric physicians, not by psychiatrists. What did the Medical Letter conclude about nefazodone? The Medical Letter [1995, 37 (946), 33-35] concluded its review of nefazodone with the words: "Available data are inadequate to determine how nefazodone compares Answered by Tierra Muehl 2 years ago.

The most important thing to know here is that this drug was pulled off the market in Canada in 2003 and pulled from the US market in 2004 (although the generic form is still available-nefazadone) due to deaths resulting from liver failure directly associated with the drug. The significant danger, despite this side effect being rare, is that it is unpredictable and happens without warning, necessitating a liver transplant. There are much safer and effective anti-depressants available and if the sexual side effects are what concern you, try wellbutrin along with prozac (same as sarafem) as it can usually combat those side effects. Answered by Willy Thaker 2 years ago.

Depression is everywhere, some brains are just wired better to cope. This is why all of the drug companies are formulating anti-depressants. My sister in law, my husband's co-worker, my mother, my grandfather, my best friends mother (who ended up going back to school and getting her doctorate in psychology to help others with depression) - all had different paths to try and deal with this. None were short. At least today it's acceptable as a legitimate illness and not looked down upon. This is why Brooke Shields wrote a book on post partum depression. There are a gazillion medications, some take awhile to work, sometimes you need a change. Please don't finish the job. If things aren't changing then you need to change your counselor, doctor and perhaps meds. Some meds can cause depression and suicidal thoughts to increase - which is why the warning labels always say to call your doc immediately if you have these thoughts. Don't feel guilty about leaving your counselor to go to another. A diploma on the wall doesn't mean they graduated with all "A's"! Are you working? If not you need to fill your time with something productive that makes you feel worthwhile. If you come really close to finishing the job, call your local crisis hotline, go to the ER. It would be best if you are not alone during this time of stabilizing on the meds. And if your insurance covers it, there is absolutely not shame in asking to be admitted to an inpatient unit where they can monitor you and your meds. My grandfather and best friends mom both went the inpatient route, as did my husband's co-worker. My sister in law had daily intensive therapy and 2 or 3 medication changes and my mother had therapy several times a week along with medication. It can be conquered! Answered by Doug Schurk 2 years ago.

Sarafem, the other drug you mention, is Prozac. It's been marketed under the name Sarafem in the US for women who have severe PMS but who might not want an antidepressant - bit of a crafty marketing ploy, and bit deceptive... Answered by Nick Russon 2 years ago.

My husband took it for about 6 months. He had a lot of weight gain so he quit. He now takes Lamictal with no side effects whatsoever. Best wishes! Answered by Dayna Tanis 2 years ago.

Serzone was an antidepressant that I took. It was taken off the market a few years ago in the U.S. when a few people in Europe died from liver failure. It worked very good for me. Answered by Gerry Mullaly 2 years ago.

Yes, it is an antidepressant medication. What would you like to know about it specifically? Answered by Carolina Hernon 2 years ago.

i have never heard of it. is it some kind of sickness or something??? Answered by Wilfredo Talk 2 years ago.

ummmmmmm no i have no idea Answered by Kathrin Meharry 2 years ago.


Anyone familiar with Ativan? How about Serzone?
I took Serzone for about 6 years and through a series of insurance problems, ended up off the Serzone and on Ativan. I've been taking "about" 2 mg. of Ativan a day for the last 1 1/2 years. ( 1/2 mg 3 times a day - 4 times max)Anyway, I made an attempt at cutting down on the Ativan yesterday by... Asked by Ileana Snarr 2 years ago.

I took Serzone for about 6 years and through a series of insurance problems, ended up off the Serzone and on Ativan. I've been taking "about" 2 mg. of Ativan a day for the last 1 1/2 years. ( 1/2 mg 3 times a day - 4 times max) Anyway, I made an attempt at cutting down on the Ativan yesterday by not taking a dose at bedtime. I woke up this morning about 3 am and just sort of layed in bed. When I got up around 6 am, I felt very strange. I just felt like crying. And I did. I took 1/2 mg dose and by 7 am I felt much better. Question: Is getting off the Ativan going to be a really bad experience? I don't want to go off my nut but I'd really like to cut the dose back. Could starting the Serzone again make it easier? Emails are welcome. Just go to my profile to email me. Thanks. Answered by Pearl Steeves 2 years ago.


Has anyone tried Serzone (Nefazodone)?
I was really looking for someone who has tried this stuff, thanks for the info though. I am aware that it can cause fatal liver failure. Asked by Jeanetta Areola 2 years ago.

I took Serzone for 3 years. I worked great. I was not able to handle the side affects of the other designer drugs like prozac or zoloft...etc. I took 2 mg of colonapin at Night for sleep and the combo worked great. My Dr. had me take a simple liver function test every six months because the med was causing some problems with liver damage (including statistically significant deaths) I stopped taking the med after I lost my health insurance. No other Dr. will per scribe it now because it is on th e"black list" I would still take it as long as I took the liver function tests periodically. Good Luck Answered by Denise Bongle 2 years ago.

Serzone sucks Answered by Cheyenne Sessum 2 years ago.


Has anyone heard of serzone?
Asked by Tristan Krumbholz 2 years ago.

What is Serzone? • Serzone is an antidepressant medication. It affects chemicals in the brain that may become unbalanced and cause depression. • Serzone is used to relieve symptoms of depression such as feelings of sadness, worthlessness, or guilt; loss of interest in daily activities; changes in appetite; tiredness; sleeping too much; insomnia; and thoughts of death or suicide. Answered by Carmina Hartjen 2 years ago.

The most important thing to know here is that this drug was pulled off the market in Canada in 2003 and pulled from the US market in 2004 (although the generic form is still available-nefazadone) due to deaths resulting from liver failure directly associated with the drug. The significant danger, despite this side effect being rare, is that it is unpredictable and happens without warning, necessitating a liver transplant. There are much safer and effective anti-depressants available and if the sexual side effects are what concern you, try wellbutrin along with prozac (same as sarafem) as it can usually combat those side effects. Answered by Willard Laviero 2 years ago.


Serzone(nefazodone) or prozac is better?
i have to start anti depressant which works more both of them can any body tell me Asked by Nona Schmied 2 years ago.

Serzone is better and here is why: It works on two brain chemicals rather than only one like Prozac Nefazodone's claimed advantages over other antidepressants include reduced possibility of disturbed sleep or sexual dysfunction, and ability to treat some patients who did not respond to other antidepressant drugs. Answered by Kirby Womack 2 years ago.


Who used to take the antidepressant Serzone that they took off the market? What medicine are you using now?
I took Serzone for a couple years in the 90s & it helped. I need a medication similiar to it. I cannot tolerate Zoloft or Paxil. Asked by Ora Roques 2 years ago.

The company that made the "brand" named "Serzone" stopped making it. It was not taken off the market. There is a company named, TEVA, that still makes and sells nefazadone, which is the medicine that Serzone is the brand of. I know because I've taken that medication for years and still take it. Hope that helps. Answered by Janeth Lutes 2 years ago.

Never took Serzone...Am on no medication for depression at present...All drugs legal or otherwise do is "mask the real problem"...Get busy, try doing for others, that will knock the "oh poor me" right out of you fast & there are no ugly side effects! Answered by Otha Verde 2 years ago.

I heard Effexor works wonders & helps with weight loss! you could use as low as a 37.5 mg dose Answered by Vanetta Clowerd 2 years ago.

I did, messed with my head. Now I take Cymbalta works great. Answered by Vertie Gibler 2 years ago.


Can Serzone be combined with Cymbalta?
My doc was looking into this when his computer went down. The cymbalta is best for pain, but the Serzone is best for depression for me. I really want to take them together. Serzone=Nefazadone Asked by Milan Strode 2 years ago.

duloxetine (cymbalta) and nefazadone (serzone) should NEVER be mixed. infact duloxetine should NEVER be mixed with any anti-depressants! the combined effects on the chemicals produced by the brain is catastrophic! it can cause permanent liver damage and increase risk of suicide. DO NOT TAKE THESE MEDS TOGETHER. consult your MD about other options, preferably a different one then prescribed you these drugs together in the fist place. good luck Answered by Ione Tenore 2 years ago.


SerZone (nefazodone)?
Hi there,I have been wanting to titrate off nefazodone for years. Does anyone have experience with the withdrawal from this medication?I have been taking 600 mg (divided doses) q day.What can I expect? Any known cases of death from withdrawal?Is it better to do it on an impatient basis?I took it for... Asked by Chi Klosner 2 years ago.

Hi there, I have been wanting to titrate off nefazodone for years. Does anyone have experience with the withdrawal from this medication? I have been taking 600 mg (divided doses) q day. What can I expect? Any known cases of death from withdrawal? Is it better to do it on an impatient basis? I took it for severe panic attacks. I am worried that the attacks will return BIGTIME. Any and all information will be helpful. Thanks, Christine Answered by Gregorio Selzler 2 years ago.

I do not know that medecine, but I went cold turkey on mine (paraxotine), and that was a terrible mistake. I felt so bad for long time after and was too stubborn to go back on. Whatever meds you're on, you should NOT stop/reduce them without doctor's advice! for your own sake! Answered by Tiffaney Gehris 2 years ago.

I have been taking Serzone for many years and am currently titrating off this drug. The process should take about six months with a 50 mg decrease every 6-8 weeks. I am experiencing some anxiety but it is manageable. Please don't try to go off without titration. JHM Answered by Avery Barger 2 years ago.


Has anyone ever taken serzone and/or cymblata?
I have been on Serzone for 7 years and just started having severe side effects and my doctor is weaning me off and starting me on cymbalta. Getting off the serzone is HELL!!!! Just wanted to know if anyone has had a similar instance.....and does Cymbalta work for anyone? Asked by Carylon Earheart 2 years ago.

Yes I am on cymbalta! I've been on it 6 months. I have no side effects from it. It has helped me out. I was put on it for chronic pain. I still have pain but not like I used too. It has been a big relief to not have so much pain in my body and joints. Hugs! Answered by Brandie Decoursey 2 years ago.

Tried the cymbalta, didnt like the side effects and stopped after 6 weeks. I thought it helped a little, very little but not worth taking for a long time. I heard it was hard to get off of it. Answered by Stephania Chinnery 2 years ago.

I am taking Cymbalta and it has worked well for me. It's like Serzone as far as getting off of it, but I haven't suffered any side effects from it. I'd suggest that you try it. Answered by Pearline Buckhalter 2 years ago.

I ended up in the hospital becasue of the side effects of Cymbalta.. BUT.. not everyone has the same side effects from every med Everyone is unique Answered by Jeanice Steele 2 years ago.


Can nefazodone (Serzone) be taken while a woman is pregnant?
Asked by Tonita Fludd 2 years ago.

It´s not advised to take it during pregnancy. It might cause a miscarriage or deformities. I would discuss this issue with a doctor not on yahoo answers !!! Answered by Deadra Verity 2 years ago.

Would definitely talk to your doctor about this as birth defects and malformities are highly probable Answered by Roselia Foste 2 years ago.

No! You should seek advice from your OBGYN. Answered by Stefan Derk 2 years ago.


Has anyone heard of serzone?
I was just reading that it is better for people to take than sarafem. It also has no sexual side effects. Asked by Rheba Mconnell 2 years ago.

Frequently Asked Questions What is nefazodone (Serzone)? Nefazodone (Serzone) is a new antidepressant with a chemical structure that is somewhat similar to that of the phenylpiperazine antidepressant, trazodone (Desyrel). The antidepressant action of nefazodone is thought to be dependent on its ability to block postsynaptic serotonin type-2 receptors and inhibit presynaptic serotonin reuptake. Nefazodone also blocks norepinephrine reuptake. Nefazodone does not have a chemical structure similar to the SSRIs, tricyclic antidepressants, monoamine oxidase inhibitors, bupropion, or venlafaxine. How does nefazodone differ from other antidepressants? One possibly important way in which nefazodone differs from other SSRIs is that while use of SSRIs is often associated with sexual dysfunction and sleep disturbances, these side-effects have been reported infrequently in people taking nefazodone. What kinds of depression can be treated with nefazodone? While the pre-marketing studies were restricted to patients with a DSM-III-R diagnosis of non-melancholic Major Depressive Disorder, it is expected that nefazodone will be prescribed for patients with Dysthymia, Major Depression, and Bipolar Disorder. Although nefazodone has mostly been studied for periods of administration of up to 8 weeks, it is expected that patients with long-standing depressions will take the drug for longer periods of time. Data on about 250 patients who took nefazodone for 12 or more months did not reveal any problems with administration for that length of time. As yet, there is no data on the effectiveness of nefazodone when used to treat patients whose depressions were so severe as to make hospitalization necessary. What are the side-effects of nefazodone? The side-effects that occurred significantly more commonly in people taking nefazodone as compared to placebo are: Side-effect Patients Dry mouth 25% Sleepiness/sedation 25% Nausea 22% Dizziness 17% Visual problems 16% Weakness 11% Lightheadedness 10% Confusion 7% Orthostatic hypotension 5% Note: The Psychopharmacology Forum of InterPsych has received one report of inappropriate erections in a patient taking nefazodone. It is expected that priapism will be reported shortly as inappropriate erections and priapism are often associated. Which side-effects force people to stop taking nefazodone? In the premarketing studies 16% of the 3496 depressed patients taking nefazodone discontinued the medication because of side-effects. The side-effects that the patients cited as the reason they dropped out that were mentioned at least twice as often for nefazodone as compared to placebo are: Side-effect Patients Nausea 3.5% Dizziness 1.9% Insomnia 1.5% Weakness 1.3% Agitation 1.2% Are there any special hazards for people with bipolar disorder? As with other antidepressants, people with bipolar disorder who are not being treated with a mood regulator such as lithium, valproate (Depakote), or carbamazepine (Tegretol) may be pushed into a manic episode when treated with nefazodone. In the pre-marketing studies, the rate of manic episodes in patients with bipolar disorder was 1.6%. Does nefazodone interact with other medications? Nefazodone increases the blood level of Seldane and Hismanal to possibly life-threatening levels. These antihistamines should never be taken while taking nefazodone. The blood levels of Halcion and Xanax are also increased by nefazodone. If Halcion is taken with nefazodone, its dose should be reduced by 75%. A reduction of 50% in the dose of Xanax is suggested if it is taken with nefazodone. Does nefazodone interact with alcohol? Although nefazodone has not been found to increase the impairment of cognitive or motor skills caused by alcohol, the manufacturer warns against drinking while taking nefazodone. Is nefazodone safe for a woman who is pregnant, about to become pregnant, or nursing an infant? There is no data to establish the safety of nefazodone for the fetus or nursing infant. Is nefazodone a satisfactory antidepressant for children and adolescents? Although there have been no published studies on the use of nefazodone for the treatment of children and adolescents with depression, it is expected that the drug will be prescribed for depressed children and adolescents. Is nefazodone a satisfactory antidepressant for the elderly? No special problems were encountered when nefazodone was studied in a group of 500 people over the age of 65 with depression. As with most drugs, when administered to the elderly, it is useful to start low and go slow. How is treatment with nefazodone initiated? Most psychiatrists start people with depression on 50 mg of nefazodone twice a day. At intervals of about one week, the dose can be increased by 100 mg per day. When nefazodone first was released the usual starting dose for adults was 100 mg twice a day. As many people found this dose to be too high, it has been replaced by a lower initial dose. When nefazodone is given to elderly patients the starting dose is usually 50 mg twice a day. What is the usual final dose of nefazodone? While doses up to 600 mg per day are approved by the FDA, some severely depressed patients have been treated with higher doses. Most depressed people respond to doses under 600 mg per day. How long does it take nefazodone to relieve depression? While most people taking nefazodone become aware of some lessening of depression within two to four weeks, there are some who experience relief within the first week and others who only experience relief after many weeks of therapy. Are there withdrawal effects if nefazodone is suddenly discontinued? A withdrawal syndrome following the abrupt discontinuation of nefazodone has not been described. Because the half-lives of nefazodone and its active metabolites are 18 hours or less, it is prudent to taper nefazodone rather than abruptly discontinue it. Is nefazodone toxic if an overdose is taken? Seven overdoses of nefazodone have been reported. The highest reported overdose was 11,200 mg. In some cases nefazodone was taken along with alcohol and/or other medications. All seven people who took an overdose recovered. What precautions are necessary when switching between nefazodone and an MAO inhibitor? When switching from an MAO inhibitor to nefazodone, there should be a 14-day interval between the discontinuation of the MAOI and the initiation of nefazodone therapy. When switching from nefazodone to an MAOI, a 7-day interval is adequate, because of nefazodone's short half-life. What does nefazodone cost? Nefazodone is supplied in tablets ranging from 100 mg to 250 mg in strength. The 100 mg tablets cost pharmacies nearly as much as the 250 mg tablets. It is expected that all strengths of nefazodone will be sold for between $0.80 and $1.25 per tablet. Might nefazodone be effective when a person has not responded to other antidepressants? Although there is no data on this, it is expected that some individuals who have failed to be helped by other antidepressants will be helped by nefazodone. What are the advantages of nefazodone? The low incidence of sexual side-effects and disturbed sleep are possible advantages of nefazodone. Has nefazodone been available in other countries? What do psychopharmacologists from those countries think of the drug? Nefazodone has been available in Canada for over six months. Most of the psychopharmacologists to whom I have spoken think that it is less effective than the SSRIs, and some have stopped writing prescriptions for it. Most of the nefazodone being prescribed in Canada is prescribed by nonpsychiatric physicians, not by psychiatrists. What did the Medical Letter conclude about nefazodone? The Medical Letter [1995, 37 (946), 33-35] concluded its review of nefazodone with the words: "Available data are inadequate to determine how nefazodone compares Answered by Rebekah Keranen 2 years ago.

The most important thing to know here is that this drug was pulled off the market in Canada in 2003 and pulled from the US market in 2004 (although the generic form is still available-nefazadone) due to deaths resulting from liver failure directly associated with the drug. The significant danger, despite this side effect being rare, is that it is unpredictable and happens without warning, necessitating a liver transplant. There are much safer and effective anti-depressants available and if the sexual side effects are what concern you, try wellbutrin along with prozac (same as sarafem) as it can usually combat those side effects. Answered by Chris Manieri 2 years ago.

Depression is everywhere, some brains are just wired better to cope. This is why all of the drug companies are formulating anti-depressants. My sister in law, my husband's co-worker, my mother, my grandfather, my best friends mother (who ended up going back to school and getting her doctorate in psychology to help others with depression) - all had different paths to try and deal with this. None were short. At least today it's acceptable as a legitimate illness and not looked down upon. This is why Brooke Shields wrote a book on post partum depression. There are a gazillion medications, some take awhile to work, sometimes you need a change. Please don't finish the job. If things aren't changing then you need to change your counselor, doctor and perhaps meds. Some meds can cause depression and suicidal thoughts to increase - which is why the warning labels always say to call your doc immediately if you have these thoughts. Don't feel guilty about leaving your counselor to go to another. A diploma on the wall doesn't mean they graduated with all "A's"! Are you working? If not you need to fill your time with something productive that makes you feel worthwhile. If you come really close to finishing the job, call your local crisis hotline, go to the ER. It would be best if you are not alone during this time of stabilizing on the meds. And if your insurance covers it, there is absolutely not shame in asking to be admitted to an inpatient unit where they can monitor you and your meds. My grandfather and best friends mom both went the inpatient route, as did my husband's co-worker. My sister in law had daily intensive therapy and 2 or 3 medication changes and my mother had therapy several times a week along with medication. It can be conquered! Answered by Karon Jungman 2 years ago.

Sarafem, the other drug you mention, is Prozac. It's been marketed under the name Sarafem in the US for women who have severe PMS but who might not want an antidepressant - bit of a crafty marketing ploy, and bit deceptive... Answered by Willetta Crossno 2 years ago.

My husband took it for about 6 months. He had a lot of weight gain so he quit. He now takes Lamictal with no side effects whatsoever. Best wishes! Answered by Rona Morren 2 years ago.

Serzone was an antidepressant that I took. It was taken off the market a few years ago in the U.S. when a few people in Europe died from liver failure. It worked very good for me. Answered by Henry Romack 2 years ago.

Yes, it is an antidepressant medication. What would you like to know about it specifically? Answered by Sharice Winterling 2 years ago.

i have never heard of it. is it some kind of sickness or something??? Answered by Clorinda Sanquenetti 2 years ago.

ummmmmmm no i have no idea Answered by Fiona Oller 2 years ago.


Anyone familiar with Ativan? How about Serzone?
I took Serzone for about 6 years and through a series of insurance problems, ended up off the Serzone and on Ativan. I've been taking "about" 2 mg. of Ativan a day for the last 1 1/2 years. ( 1/2 mg 3 times a day - 4 times max)Anyway, I made an attempt at cutting down on the Ativan yesterday by... Asked by Eleonor Lipan 2 years ago.

I took Serzone for about 6 years and through a series of insurance problems, ended up off the Serzone and on Ativan. I've been taking "about" 2 mg. of Ativan a day for the last 1 1/2 years. ( 1/2 mg 3 times a day - 4 times max) Anyway, I made an attempt at cutting down on the Ativan yesterday by not taking a dose at bedtime. I woke up this morning about 3 am and just sort of layed in bed. When I got up around 6 am, I felt very strange. I just felt like crying. And I did. I took 1/2 mg dose and by 7 am I felt much better. Question: Is getting off the Ativan going to be a really bad experience? I don't want to go off my nut but I'd really like to cut the dose back. Could starting the Serzone again make it easier? Emails are welcome. Just go to my profile to email me. Thanks. Answered by Erasmo Hagar 2 years ago.


Has anyone tried Serzone (Nefazodone)?
I was really looking for someone who has tried this stuff, thanks for the info though. I am aware that it can cause fatal liver failure. Asked by Efren Schiavo 2 years ago.

I took Serzone for 3 years. I worked great. I was not able to handle the side affects of the other designer drugs like prozac or zoloft...etc. I took 2 mg of colonapin at Night for sleep and the combo worked great. My Dr. had me take a simple liver function test every six months because the med was causing some problems with liver damage (including statistically significant deaths) I stopped taking the med after I lost my health insurance. No other Dr. will per scribe it now because it is on th e"black list" I would still take it as long as I took the liver function tests periodically. Good Luck Answered by Jonell Almaraz 2 years ago.

Serzone sucks Answered by Roselle Zappia 2 years ago.


Has anyone heard of serzone?
Asked by Meda Crusan 2 years ago.

What is Serzone? • Serzone is an antidepressant medication. It affects chemicals in the brain that may become unbalanced and cause depression. • Serzone is used to relieve symptoms of depression such as feelings of sadness, worthlessness, or guilt; loss of interest in daily activities; changes in appetite; tiredness; sleeping too much; insomnia; and thoughts of death or suicide. Answered by Lorean Clines 2 years ago.

The most important thing to know here is that this drug was pulled off the market in Canada in 2003 and pulled from the US market in 2004 (although the generic form is still available-nefazadone) due to deaths resulting from liver failure directly associated with the drug. The significant danger, despite this side effect being rare, is that it is unpredictable and happens without warning, necessitating a liver transplant. There are much safer and effective anti-depressants available and if the sexual side effects are what concern you, try wellbutrin along with prozac (same as sarafem) as it can usually combat those side effects. Answered by Cherelle Algier 2 years ago.


Serzone(nefazodone) or prozac is better?
i have to start anti depressant which works more both of them can any body tell me Asked by Kathyrn Forlivio 2 years ago.

Serzone is better and here is why: It works on two brain chemicals rather than only one like Prozac Nefazodone's claimed advantages over other antidepressants include reduced possibility of disturbed sleep or sexual dysfunction, and ability to treat some patients who did not respond to other antidepressant drugs. Answered by Judson Leffingwell 2 years ago.


Who used to take the antidepressant Serzone that they took off the market? What medicine are you using now?
I took Serzone for a couple years in the 90s & it helped. I need a medication similiar to it. I cannot tolerate Zoloft or Paxil. Asked by Marva Hoglan 2 years ago.

The company that made the "brand" named "Serzone" stopped making it. It was not taken off the market. There is a company named, TEVA, that still makes and sells nefazadone, which is the medicine that Serzone is the brand of. I know because I've taken that medication for years and still take it. Hope that helps. Answered by Rudolph Meek 2 years ago.

Never took Serzone...Am on no medication for depression at present...All drugs legal or otherwise do is "mask the real problem"...Get busy, try doing for others, that will knock the "oh poor me" right out of you fast & there are no ugly side effects! Answered by Loreen Strife 2 years ago.

I heard Effexor works wonders & helps with weight loss! you could use as low as a 37.5 mg dose Answered by Thresa Giampapa 2 years ago.

I did, messed with my head. Now I take Cymbalta works great. Answered by Mirian Camero 2 years ago.


Can Serzone be combined with Cymbalta?
My doc was looking into this when his computer went down. The cymbalta is best for pain, but the Serzone is best for depression for me. I really want to take them together. Serzone=Nefazadone Asked by Lia Caton 2 years ago.

duloxetine (cymbalta) and nefazadone (serzone) should NEVER be mixed. infact duloxetine should NEVER be mixed with any anti-depressants! the combined effects on the chemicals produced by the brain is catastrophic! it can cause permanent liver damage and increase risk of suicide. DO NOT TAKE THESE MEDS TOGETHER. consult your MD about other options, preferably a different one then prescribed you these drugs together in the fist place. good luck Answered by Denita Zadra 2 years ago.


SerZone (nefazodone)?
Hi there,I have been wanting to titrate off nefazodone for years. Does anyone have experience with the withdrawal from this medication?I have been taking 600 mg (divided doses) q day.What can I expect? Any known cases of death from withdrawal?Is it better to do it on an impatient basis?I took it for... Asked by Arnulfo Mcshane 2 years ago.

Hi there, I have been wanting to titrate off nefazodone for years. Does anyone have experience with the withdrawal from this medication? I have been taking 600 mg (divided doses) q day. What can I expect? Any known cases of death from withdrawal? Is it better to do it on an impatient basis? I took it for severe panic attacks. I am worried that the attacks will return BIGTIME. Any and all information will be helpful. Thanks, Christine Answered by Steven Shakoor 2 years ago.

I do not know that medecine, but I went cold turkey on mine (paraxotine), and that was a terrible mistake. I felt so bad for long time after and was too stubborn to go back on. Whatever meds you're on, you should NOT stop/reduce them without doctor's advice! for your own sake! Answered by Whitney Felber 2 years ago.

I have been taking Serzone for many years and am currently titrating off this drug. The process should take about six months with a 50 mg decrease every 6-8 weeks. I am experiencing some anxiety but it is manageable. Please don't try to go off without titration. JHM Answered by Nohemi Salzberg 2 years ago.


Has anyone ever taken serzone and/or cymblata?
I have been on Serzone for 7 years and just started having severe side effects and my doctor is weaning me off and starting me on cymbalta. Getting off the serzone is HELL!!!! Just wanted to know if anyone has had a similar instance.....and does Cymbalta work for anyone? Asked by Kelle Pagdanganan 2 years ago.

Yes I am on cymbalta! I've been on it 6 months. I have no side effects from it. It has helped me out. I was put on it for chronic pain. I still have pain but not like I used too. It has been a big relief to not have so much pain in my body and joints. Hugs! Answered by Ralph Coonley 2 years ago.

Tried the cymbalta, didnt like the side effects and stopped after 6 weeks. I thought it helped a little, very little but not worth taking for a long time. I heard it was hard to get off of it. Answered by Zenia Boss 2 years ago.

I am taking Cymbalta and it has worked well for me. It's like Serzone as far as getting off of it, but I haven't suffered any side effects from it. I'd suggest that you try it. Answered by Diedra Scargall 2 years ago.

I ended up in the hospital becasue of the side effects of Cymbalta.. BUT.. not everyone has the same side effects from every med Everyone is unique Answered by Justa Jonsson 2 years ago.


Can nefazodone (Serzone) be taken while a woman is pregnant?
Asked by Dagny Siefkes 2 years ago.

It´s not advised to take it during pregnancy. It might cause a miscarriage or deformities. I would discuss this issue with a doctor not on yahoo answers !!! Answered by Mitzi Dowd 2 years ago.

Would definitely talk to your doctor about this as birth defects and malformities are highly probable Answered by Tamera Burgie 2 years ago.

No! You should seek advice from your OBGYN. Answered by Emily Bounthapanya 2 years ago.


Has anyone heard of serzone?
I was just reading that it is better for people to take than sarafem. It also has no sexual side effects. Asked by Tiesha Waguespack 2 years ago.

Frequently Asked Questions What is nefazodone (Serzone)? Nefazodone (Serzone) is a new antidepressant with a chemical structure that is somewhat similar to that of the phenylpiperazine antidepressant, trazodone (Desyrel). The antidepressant action of nefazodone is thought to be dependent on its ability to block postsynaptic serotonin type-2 receptors and inhibit presynaptic serotonin reuptake. Nefazodone also blocks norepinephrine reuptake. Nefazodone does not have a chemical structure similar to the SSRIs, tricyclic antidepressants, monoamine oxidase inhibitors, bupropion, or venlafaxine. How does nefazodone differ from other antidepressants? One possibly important way in which nefazodone differs from other SSRIs is that while use of SSRIs is often associated with sexual dysfunction and sleep disturbances, these side-effects have been reported infrequently in people taking nefazodone. What kinds of depression can be treated with nefazodone? While the pre-marketing studies were restricted to patients with a DSM-III-R diagnosis of non-melancholic Major Depressive Disorder, it is expected that nefazodone will be prescribed for patients with Dysthymia, Major Depression, and Bipolar Disorder. Although nefazodone has mostly been studied for periods of administration of up to 8 weeks, it is expected that patients with long-standing depressions will take the drug for longer periods of time. Data on about 250 patients who took nefazodone for 12 or more months did not reveal any problems with administration for that length of time. As yet, there is no data on the effectiveness of nefazodone when used to treat patients whose depressions were so severe as to make hospitalization necessary. What are the side-effects of nefazodone? The side-effects that occurred significantly more commonly in people taking nefazodone as compared to placebo are: Side-effect Patients Dry mouth 25% Sleepiness/sedation 25% Nausea 22% Dizziness 17% Visual problems 16% Weakness 11% Lightheadedness 10% Confusion 7% Orthostatic hypotension 5% Note: The Psychopharmacology Forum of InterPsych has received one report of inappropriate erections in a patient taking nefazodone. It is expected that priapism will be reported shortly as inappropriate erections and priapism are often associated. Which side-effects force people to stop taking nefazodone? In the premarketing studies 16% of the 3496 depressed patients taking nefazodone discontinued the medication because of side-effects. The side-effects that the patients cited as the reason they dropped out that were mentioned at least twice as often for nefazodone as compared to placebo are: Side-effect Patients Nausea 3.5% Dizziness 1.9% Insomnia 1.5% Weakness 1.3% Agitation 1.2% Are there any special hazards for people with bipolar disorder? As with other antidepressants, people with bipolar disorder who are not being treated with a mood regulator such as lithium, valproate (Depakote), or carbamazepine (Tegretol) may be pushed into a manic episode when treated with nefazodone. In the pre-marketing studies, the rate of manic episodes in patients with bipolar disorder was 1.6%. Does nefazodone interact with other medications? Nefazodone increases the blood level of Seldane and Hismanal to possibly life-threatening levels. These antihistamines should never be taken while taking nefazodone. The blood levels of Halcion and Xanax are also increased by nefazodone. If Halcion is taken with nefazodone, its dose should be reduced by 75%. A reduction of 50% in the dose of Xanax is suggested if it is taken with nefazodone. Does nefazodone interact with alcohol? Although nefazodone has not been found to increase the impairment of cognitive or motor skills caused by alcohol, the manufacturer warns against drinking while taking nefazodone. Is nefazodone safe for a woman who is pregnant, about to become pregnant, or nursing an infant? There is no data to establish the safety of nefazodone for the fetus or nursing infant. Is nefazodone a satisfactory antidepressant for children and adolescents? Although there have been no published studies on the use of nefazodone for the treatment of children and adolescents with depression, it is expected that the drug will be prescribed for depressed children and adolescents. Is nefazodone a satisfactory antidepressant for the elderly? No special problems were encountered when nefazodone was studied in a group of 500 people over the age of 65 with depression. As with most drugs, when administered to the elderly, it is useful to start low and go slow. How is treatment with nefazodone initiated? Most psychiatrists start people with depression on 50 mg of nefazodone twice a day. At intervals of about one week, the dose can be increased by 100 mg per day. When nefazodone first was released the usual starting dose for adults was 100 mg twice a day. As many people found this dose to be too high, it has been replaced by a lower initial dose. When nefazodone is given to elderly patients the starting dose is usually 50 mg twice a day. What is the usual final dose of nefazodone? While doses up to 600 mg per day are approved by the FDA, some severely depressed patients have been treated with higher doses. Most depressed people respond to doses under 600 mg per day. How long does it take nefazodone to relieve depression? While most people taking nefazodone become aware of some lessening of depression within two to four weeks, there are some who experience relief within the first week and others who only experience relief after many weeks of therapy. Are there withdrawal effects if nefazodone is suddenly discontinued? A withdrawal syndrome following the abrupt discontinuation of nefazodone has not been described. Because the half-lives of nefazodone and its active metabolites are 18 hours or less, it is prudent to taper nefazodone rather than abruptly discontinue it. Is nefazodone toxic if an overdose is taken? Seven overdoses of nefazodone have been reported. The highest reported overdose was 11,200 mg. In some cases nefazodone was taken along with alcohol and/or other medications. All seven people who took an overdose recovered. What precautions are necessary when switching between nefazodone and an MAO inhibitor? When switching from an MAO inhibitor to nefazodone, there should be a 14-day interval between the discontinuation of the MAOI and the initiation of nefazodone therapy. When switching from nefazodone to an MAOI, a 7-day interval is adequate, because of nefazodone's short half-life. What does nefazodone cost? Nefazodone is supplied in tablets ranging from 100 mg to 250 mg in strength. The 100 mg tablets cost pharmacies nearly as much as the 250 mg tablets. It is expected that all strengths of nefazodone will be sold for between $0.80 and $1.25 per tablet. Might nefazodone be effective when a person has not responded to other antidepressants? Although there is no data on this, it is expected that some individuals who have failed to be helped by other antidepressants will be helped by nefazodone. What are the advantages of nefazodone? The low incidence of sexual side-effects and disturbed sleep are possible advantages of nefazodone. Has nefazodone been available in other countries? What do psychopharmacologists from those countries think of the drug? Nefazodone has been available in Canada for over six months. Most of the psychopharmacologists to whom I have spoken think that it is less effective than the SSRIs, and some have stopped writing prescriptions for it. Most of the nefazodone being prescribed in Canada is prescribed by nonpsychiatric physicians, not by psychiatrists. What did the Medical Letter conclude about nefazodone? The Medical Letter [1995, 37 (946), 33-35] concluded its review of nefazodone with the words: "Available data are inadequate to determine how nefazodone compares Answered by Isobel Techaira 2 years ago.

The most important thing to know here is that this drug was pulled off the market in Canada in 2003 and pulled from the US market in 2004 (although the generic form is still available-nefazadone) due to deaths resulting from liver failure directly associated with the drug. The significant danger, despite this side effect being rare, is that it is unpredictable and happens without warning, necessitating a liver transplant. There are much safer and effective anti-depressants available and if the sexual side effects are what concern you, try wellbutrin along with prozac (same as sarafem) as it can usually combat those side effects. Answered by Daine Oehlenschlage 2 years ago.

Depression is everywhere, some brains are just wired better to cope. This is why all of the drug companies are formulating anti-depressants. My sister in law, my husband's co-worker, my mother, my grandfather, my best friends mother (who ended up going back to school and getting her doctorate in psychology to help others with depression) - all had different paths to try and deal with this. None were short. At least today it's acceptable as a legitimate illness and not looked down upon. This is why Brooke Shields wrote a book on post partum depression. There are a gazillion medications, some take awhile to work, sometimes you need a change. Please don't finish the job. If things aren't changing then you need to change your counselor, doctor and perhaps meds. Some meds can cause depression and suicidal thoughts to increase - which is why the warning labels always say to call your doc immediately if you have these thoughts. Don't feel guilty about leaving your counselor to go to another. A diploma on the wall doesn't mean they graduated with all "A's"! Are you working? If not you need to fill your time with something productive that makes you feel worthwhile. If you come really close to finishing the job, call your local crisis hotline, go to the ER. It would be best if you are not alone during this time of stabilizing on the meds. And if your insurance covers it, there is absolutely not shame in asking to be admitted to an inpatient unit where they can monitor you and your meds. My grandfather and best friends mom both went the inpatient route, as did my husband's co-worker. My sister in law had daily intensive therapy and 2 or 3 medication changes and my mother had therapy several times a week along with medication. It can be conquered! Answered by Shiloh Nydick 2 years ago.

Sarafem, the other drug you mention, is Prozac. It's been marketed under the name Sarafem in the US for women who have severe PMS but who might not want an antidepressant - bit of a crafty marketing ploy, and bit deceptive... Answered by Sheilah Thackaberry 2 years ago.

My husband took it for about 6 months. He had a lot of weight gain so he quit. He now takes Lamictal with no side effects whatsoever. Best wishes! Answered by Willa Halsema 2 years ago.

Serzone was an antidepressant that I took. It was taken off the market a few years ago in the U.S. when a few people in Europe died from liver failure. It worked very good for me. Answered by Keneth Struchen 2 years ago.

Yes, it is an antidepressant medication. What would you like to know about it specifically? Answered by Alia Marbut 2 years ago.

i have never heard of it. is it some kind of sickness or something??? Answered by Minda Khela 2 years ago.

ummmmmmm no i have no idea Answered by Chris Ripoll 2 years ago.


Anyone familiar with Ativan? How about Serzone?
I took Serzone for about 6 years and through a series of insurance problems, ended up off the Serzone and on Ativan. I've been taking "about" 2 mg. of Ativan a day for the last 1 1/2 years. ( 1/2 mg 3 times a day - 4 times max)Anyway, I made an attempt at cutting down on the Ativan yesterday by... Asked by Lionel Magil 2 years ago.

I took Serzone for about 6 years and through a series of insurance problems, ended up off the Serzone and on Ativan. I've been taking "about" 2 mg. of Ativan a day for the last 1 1/2 years. ( 1/2 mg 3 times a day - 4 times max) Anyway, I made an attempt at cutting down on the Ativan yesterday by not taking a dose at bedtime. I woke up this morning about 3 am and just sort of layed in bed. When I got up around 6 am, I felt very strange. I just felt like crying. And I did. I took 1/2 mg dose and by 7 am I felt much better. Question: Is getting off the Ativan going to be a really bad experience? I don't want to go off my nut but I'd really like to cut the dose back. Could starting the Serzone again make it easier? Emails are welcome. Just go to my profile to email me. Thanks. Answered by John Griffel 2 years ago.


Has anyone tried Serzone (Nefazodone)?
I was really looking for someone who has tried this stuff, thanks for the info though. I am aware that it can cause fatal liver failure. Asked by Jone Dronick 2 years ago.

I took Serzone for 3 years. I worked great. I was not able to handle the side affects of the other designer drugs like prozac or zoloft...etc. I took 2 mg of colonapin at Night for sleep and the combo worked great. My Dr. had me take a simple liver function test every six months because the med was causing some problems with liver damage (including statistically significant deaths) I stopped taking the med after I lost my health insurance. No other Dr. will per scribe it now because it is on th e"black list" I would still take it as long as I took the liver function tests periodically. Good Luck Answered by Stepanie Howkins 2 years ago.

Serzone sucks Answered by Elinore Enyart 2 years ago.


Has anyone heard of serzone?
Asked by Tania Kevwitch 2 years ago.

What is Serzone? • Serzone is an antidepressant medication. It affects chemicals in the brain that may become unbalanced and cause depression. • Serzone is used to relieve symptoms of depression such as feelings of sadness, worthlessness, or guilt; loss of interest in daily activities; changes in appetite; tiredness; sleeping too much; insomnia; and thoughts of death or suicide. Answered by Beau Rinard 2 years ago.

The most important thing to know here is that this drug was pulled off the market in Canada in 2003 and pulled from the US market in 2004 (although the generic form is still available-nefazadone) due to deaths resulting from liver failure directly associated with the drug. The significant danger, despite this side effect being rare, is that it is unpredictable and happens without warning, necessitating a liver transplant. There are much safer and effective anti-depressants available and if the sexual side effects are what concern you, try wellbutrin along with prozac (same as sarafem) as it can usually combat those side effects. Answered by Harriet Rynders 2 years ago.


Serzone(nefazodone) or prozac is better?
i have to start anti depressant which works more both of them can any body tell me Asked by Etsuko Lugones 2 years ago.

Serzone is better and here is why: It works on two brain chemicals rather than only one like Prozac Nefazodone's claimed advantages over other antidepressants include reduced possibility of disturbed sleep or sexual dysfunction, and ability to treat some patients who did not respond to other antidepressant drugs. Answered by Leah Morisey 2 years ago.


Who used to take the antidepressant Serzone that they took off the market? What medicine are you using now?
I took Serzone for a couple years in the 90s & it helped. I need a medication similiar to it. I cannot tolerate Zoloft or Paxil. Asked by Stefanie Curbelo 2 years ago.

The company that made the "brand" named "Serzone" stopped making it. It was not taken off the market. There is a company named, TEVA, that still makes and sells nefazadone, which is the medicine that Serzone is the brand of. I know because I've taken that medication for years and still take it. Hope that helps. Answered by Stanton Zilahi 2 years ago.

Never took Serzone...Am on no medication for depression at present...All drugs legal or otherwise do is "mask the real problem"...Get busy, try doing for others, that will knock the "oh poor me" right out of you fast & there are no ugly side effects! Answered by Gaye Mcatee 2 years ago.

I heard Effexor works wonders & helps with weight loss! you could use as low as a 37.5 mg dose Answered by Johanna Kersey 2 years ago.

I did, messed with my head. Now I take Cymbalta works great. Answered by Debroah Reagin 2 years ago.


Can Serzone be combined with Cymbalta?
My doc was looking into this when his computer went down. The cymbalta is best for pain, but the Serzone is best for depression for me. I really want to take them together. Serzone=Nefazadone Asked by Romeo Noecker 2 years ago.

duloxetine (cymbalta) and nefazadone (serzone) should NEVER be mixed. infact duloxetine should NEVER be mixed with any anti-depressants! the combined effects on the chemicals produced by the brain is catastrophic! it can cause permanent liver damage and increase risk of suicide. DO NOT TAKE THESE MEDS TOGETHER. consult your MD about other options, preferably a different one then prescribed you these drugs together in the fist place. good luck Answered by Tawanna Fallaw 2 years ago.


SerZone (nefazodone)?
Hi there,I have been wanting to titrate off nefazodone for years. Does anyone have experience with the withdrawal from this medication?I have been taking 600 mg (divided doses) q day.What can I expect? Any known cases of death from withdrawal?Is it better to do it on an impatient basis?I took it for... Asked by Jed Feigh 2 years ago.

Hi there, I have been wanting to titrate off nefazodone for years. Does anyone have experience with the withdrawal from this medication? I have been taking 600 mg (divided doses) q day. What can I expect? Any known cases of death from withdrawal? Is it better to do it on an impatient basis? I took it for severe panic attacks. I am worried that the attacks will return BIGTIME. Any and all information will be helpful. Thanks, Christine Answered by Doretha Macera 2 years ago.

I do not know that medecine, but I went cold turkey on mine (paraxotine), and that was a terrible mistake. I felt so bad for long time after and was too stubborn to go back on. Whatever meds you're on, you should NOT stop/reduce them without doctor's advice! for your own sake! Answered by Chrissy Bowar 2 years ago.

I have been taking Serzone for many years and am currently titrating off this drug. The process should take about six months with a 50 mg decrease every 6-8 weeks. I am experiencing some anxiety but it is manageable. Please don't try to go off without titration. JHM Answered by Sandi Hohiudden 2 years ago.


Has anyone ever taken serzone and/or cymblata?
I have been on Serzone for 7 years and just started having severe side effects and my doctor is weaning me off and starting me on cymbalta. Getting off the serzone is HELL!!!! Just wanted to know if anyone has had a similar instance.....and does Cymbalta work for anyone? Asked by Jerrica Black 2 years ago.

Yes I am on cymbalta! I've been on it 6 months. I have no side effects from it. It has helped me out. I was put on it for chronic pain. I still have pain but not like I used too. It has been a big relief to not have so much pain in my body and joints. Hugs! Answered by Ignacia Morningstar 2 years ago.

Tried the cymbalta, didnt like the side effects and stopped after 6 weeks. I thought it helped a little, very little but not worth taking for a long time. I heard it was hard to get off of it. Answered by Tanya Bielke 2 years ago.

I am taking Cymbalta and it has worked well for me. It's like Serzone as far as getting off of it, but I haven't suffered any side effects from it. I'd suggest that you try it. Answered by Samuel Forcade 2 years ago.

I ended up in the hospital becasue of the side effects of Cymbalta.. BUT.. not everyone has the same side effects from every med Everyone is unique Answered by Aimee Connon 2 years ago.


Can nefazodone (Serzone) be taken while a woman is pregnant?
Asked by Aaron Brzezinski 2 years ago.

It´s not advised to take it during pregnancy. It might cause a miscarriage or deformities. I would discuss this issue with a doctor not on yahoo answers !!! Answered by Malissa Swoope 2 years ago.

Would definitely talk to your doctor about this as birth defects and malformities are highly probable Answered by Letisha Caddle 2 years ago.

No! You should seek advice from your OBGYN. Answered by Weston Floan 2 years ago.


Has anyone heard of serzone?
I was just reading that it is better for people to take than sarafem. It also has no sexual side effects. Asked by Alia Feliu 2 years ago.

Frequently Asked Questions What is nefazodone (Serzone)? Nefazodone (Serzone) is a new antidepressant with a chemical structure that is somewhat similar to that of the phenylpiperazine antidepressant, trazodone (Desyrel). The antidepressant action of nefazodone is thought to be dependent on its ability to block postsynaptic serotonin type-2 receptors and inhibit presynaptic serotonin reuptake. Nefazodone also blocks norepinephrine reuptake. Nefazodone does not have a chemical structure similar to the SSRIs, tricyclic antidepressants, monoamine oxidase inhibitors, bupropion, or venlafaxine. How does nefazodone differ from other antidepressants? One possibly important way in which nefazodone differs from other SSRIs is that while use of SSRIs is often associated with sexual dysfunction and sleep disturbances, these side-effects have been reported infrequently in people taking nefazodone. What kinds of depression can be treated with nefazodone? While the pre-marketing studies were restricted to patients with a DSM-III-R diagnosis of non-melancholic Major Depressive Disorder, it is expected that nefazodone will be prescribed for patients with Dysthymia, Major Depression, and Bipolar Disorder. Although nefazodone has mostly been studied for periods of administration of up to 8 weeks, it is expected that patients with long-standing depressions will take the drug for longer periods of time. Data on about 250 patients who took nefazodone for 12 or more months did not reveal any problems with administration for that length of time. As yet, there is no data on the effectiveness of nefazodone when used to treat patients whose depressions were so severe as to make hospitalization necessary. What are the side-effects of nefazodone? The side-effects that occurred significantly more commonly in people taking nefazodone as compared to placebo are: Side-effect Patients Dry mouth 25% Sleepiness/sedation 25% Nausea 22% Dizziness 17% Visual problems 16% Weakness 11% Lightheadedness 10% Confusion 7% Orthostatic hypotension 5% Note: The Psychopharmacology Forum of InterPsych has received one report of inappropriate erections in a patient taking nefazodone. It is expected that priapism will be reported shortly as inappropriate erections and priapism are often associated. Which side-effects force people to stop taking nefazodone? In the premarketing studies 16% of the 3496 depressed patients taking nefazodone discontinued the medication because of side-effects. The side-effects that the patients cited as the reason they dropped out that were mentioned at least twice as often for nefazodone as compared to placebo are: Side-effect Patients Nausea 3.5% Dizziness 1.9% Insomnia 1.5% Weakness 1.3% Agitation 1.2% Are there any special hazards for people with bipolar disorder? As with other antidepressants, people with bipolar disorder who are not being treated with a mood regulator such as lithium, valproate (Depakote), or carbamazepine (Tegretol) may be pushed into a manic episode when treated with nefazodone. In the pre-marketing studies, the rate of manic episodes in patients with bipolar disorder was 1.6%. Does nefazodone interact with other medications? Nefazodone increases the blood level of Seldane and Hismanal to possibly life-threatening levels. These antihistamines should never be taken while taking nefazodone. The blood levels of Halcion and Xanax are also increased by nefazodone. If Halcion is taken with nefazodone, its dose should be reduced by 75%. A reduction of 50% in the dose of Xanax is suggested if it is taken with nefazodone. Does nefazodone interact with alcohol? Although nefazodone has not been found to increase the impairment of cognitive or motor skills caused by alcohol, the manufacturer warns against drinking while taking nefazodone. Is nefazodone safe for a woman who is pregnant, about to become pregnant, or nursing an infant? There is no data to establish the safety of nefazodone for the fetus or nursing infant. Is nefazodone a satisfactory antidepressant for children and adolescents? Although there have been no published studies on the use of nefazodone for the treatment of children and adolescents with depression, it is expected that the drug will be prescribed for depressed children and adolescents. Is nefazodone a satisfactory antidepressant for the elderly? No special problems were encountered when nefazodone was studied in a group of 500 people over the age of 65 with depression. As with most drugs, when administered to the elderly, it is useful to start low and go slow. How is treatment with nefazodone initiated? Most psychiatrists start people with depression on 50 mg of nefazodone twice a day. At intervals of about one week, the dose can be increased by 100 mg per day. When nefazodone first was released the usual starting dose for adults was 100 mg twice a day. As many people found this dose to be too high, it has been replaced by a lower initial dose. When nefazodone is given to elderly patients the starting dose is usually 50 mg twice a day. What is the usual final dose of nefazodone? While doses up to 600 mg per day are approved by the FDA, some severely depressed patients have been treated with higher doses. Most depressed people respond to doses under 600 mg per day. How long does it take nefazodone to relieve depression? While most people taking nefazodone become aware of some lessening of depression within two to four weeks, there are some who experience relief within the first week and others who only experience relief after many weeks of therapy. Are there withdrawal effects if nefazodone is suddenly discontinued? A withdrawal syndrome following the abrupt discontinuation of nefazodone has not been described. Because the half-lives of nefazodone and its active metabolites are 18 hours or less, it is prudent to taper nefazodone rather than abruptly discontinue it. Is nefazodone toxic if an overdose is taken? Seven overdoses of nefazodone have been reported. The highest reported overdose was 11,200 mg. In some cases nefazodone was taken along with alcohol and/or other medications. All seven people who took an overdose recovered. What precautions are necessary when switching between nefazodone and an MAO inhibitor? When switching from an MAO inhibitor to nefazodone, there should be a 14-day interval between the discontinuation of the MAOI and the initiation of nefazodone therapy. When switching from nefazodone to an MAOI, a 7-day interval is adequate, because of nefazodone's short half-life. What does nefazodone cost? Nefazodone is supplied in tablets ranging from 100 mg to 250 mg in strength. The 100 mg tablets cost pharmacies nearly as much as the 250 mg tablets. It is expected that all strengths of nefazodone will be sold for between $0.80 and $1.25 per tablet. Might nefazodone be effective when a person has not responded to other antidepressants? Although there is no data on this, it is expected that some individuals who have failed to be helped by other antidepressants will be helped by nefazodone. What are the advantages of nefazodone? The low incidence of sexual side-effects and disturbed sleep are possible advantages of nefazodone. Has nefazodone been available in other countries? What do psychopharmacologists from those countries think of the drug? Nefazodone has been available in Canada for over six months. Most of the psychopharmacologists to whom I have spoken think that it is less effective than the SSRIs, and some have stopped writing prescriptions for it. Most of the nefazodone being prescribed in Canada is prescribed by nonpsychiatric physicians, not by psychiatrists. What did the Medical Letter conclude about nefazodone? The Medical Letter [1995, 37 (946), 33-35] concluded its review of nefazodone with the words: "Available data are inadequate to determine how nefazodone compares Answered by Leslee Maeder 2 years ago.

The most important thing to know here is that this drug was pulled off the market in Canada in 2003 and pulled from the US market in 2004 (although the generic form is still available-nefazadone) due to deaths resulting from liver failure directly associated with the drug. The significant danger, despite this side effect being rare, is that it is unpredictable and happens without warning, necessitating a liver transplant. There are much safer and effective anti-depressants available and if the sexual side effects are what concern you, try wellbutrin along with prozac (same as sarafem) as it can usually combat those side effects. Answered by Carmelina Villiard 2 years ago.

Depression is everywhere, some brains are just wired better to cope. This is why all of the drug companies are formulating anti-depressants. My sister in law, my husband's co-worker, my mother, my grandfather, my best friends mother (who ended up going back to school and getting her doctorate in psychology to help others with depression) - all had different paths to try and deal with this. None were short. At least today it's acceptable as a legitimate illness and not looked down upon. This is why Brooke Shields wrote a book on post partum depression. There are a gazillion medications, some take awhile to work, sometimes you need a change. Please don't finish the job. If things aren't changing then you need to change your counselor, doctor and perhaps meds. Some meds can cause depression and suicidal thoughts to increase - which is why the warning labels always say to call your doc immediately if you have these thoughts. Don't feel guilty about leaving your counselor to go to another. A diploma on the wall doesn't mean they graduated with all "A's"! Are you working? If not you need to fill your time with something productive that makes you feel worthwhile. If you come really close to finishing the job, call your local crisis hotline, go to the ER. It would be best if you are not alone during this time of stabilizing on the meds. And if your insurance covers it, there is absolutely not shame in asking to be admitted to an inpatient unit where they can monitor you and your meds. My grandfather and best friends mom both went the inpatient route, as did my husband's co-worker. My sister in law had daily intensive therapy and 2 or 3 medication changes and my mother had therapy several times a week along with medication. It can be conquered! Answered by Edwardo Soules 2 years ago.

Sarafem, the other drug you mention, is Prozac. It's been marketed under the name Sarafem in the US for women who have severe PMS but who might not want an antidepressant - bit of a crafty marketing ploy, and bit deceptive... Answered by Sheryl Otsman 2 years ago.

My husband took it for about 6 months. He had a lot of weight gain so he quit. He now takes Lamictal with no side effects whatsoever. Best wishes! Answered by Corey Parson 2 years ago.

Serzone was an antidepressant that I took. It was taken off the market a few years ago in the U.S. when a few people in Europe died from liver failure. It worked very good for me. Answered by Nathaniel Buchtel 2 years ago.

Yes, it is an antidepressant medication. What would you like to know about it specifically? Answered by Kenisha Reinken 2 years ago.

i have never heard of it. is it some kind of sickness or something??? Answered by Valda Fulenwider 2 years ago.

ummmmmmm no i have no idea Answered by Tran Feldner 2 years ago.


Anyone familiar with Ativan? How about Serzone?
I took Serzone for about 6 years and through a series of insurance problems, ended up off the Serzone and on Ativan. I've been taking "about" 2 mg. of Ativan a day for the last 1 1/2 years. ( 1/2 mg 3 times a day - 4 times max)Anyway, I made an attempt at cutting down on the Ativan yesterday by... Asked by Elmo Womeldorf 2 years ago.

I took Serzone for about 6 years and through a series of insurance problems, ended up off the Serzone and on Ativan. I've been taking "about" 2 mg. of Ativan a day for the last 1 1/2 years. ( 1/2 mg 3 times a day - 4 times max) Anyway, I made an attempt at cutting down on the Ativan yesterday by not taking a dose at bedtime. I woke up this morning about 3 am and just sort of layed in bed. When I got up around 6 am, I felt very strange. I just felt like crying. And I did. I took 1/2 mg dose and by 7 am I felt much better. Question: Is getting off the Ativan going to be a really bad experience? I don't want to go off my nut but I'd really like to cut the dose back. Could starting the Serzone again make it easier? Emails are welcome. Just go to my profile to email me. Thanks. Answered by Kim Squibb 2 years ago.


Has anyone tried Serzone (Nefazodone)?
I was really looking for someone who has tried this stuff, thanks for the info though. I am aware that it can cause fatal liver failure. Asked by Tawanna Fore 2 years ago.

I took Serzone for 3 years. I worked great. I was not able to handle the side affects of the other designer drugs like prozac or zoloft...etc. I took 2 mg of colonapin at Night for sleep and the combo worked great. My Dr. had me take a simple liver function test every six months because the med was causing some problems with liver damage (including statistically significant deaths) I stopped taking the med after I lost my health insurance. No other Dr. will per scribe it now because it is on th e"black list" I would still take it as long as I took the liver function tests periodically. Good Luck Answered by Merrill Dugi 2 years ago.

Serzone sucks Answered by Cathy Brew 2 years ago.


Has anyone heard of serzone?
Asked by Pierre Kieger 2 years ago.

What is Serzone? • Serzone is an antidepressant medication. It affects chemicals in the brain that may become unbalanced and cause depression. • Serzone is used to relieve symptoms of depression such as feelings of sadness, worthlessness, or guilt; loss of interest in daily activities; changes in appetite; tiredness; sleeping too much; insomnia; and thoughts of death or suicide. Answered by Shanti Aggarwal 2 years ago.

The most important thing to know here is that this drug was pulled off the market in Canada in 2003 and pulled from the US market in 2004 (although the generic form is still available-nefazadone) due to deaths resulting from liver failure directly associated with the drug. The significant danger, despite this side effect being rare, is that it is unpredictable and happens without warning, necessitating a liver transplant. There are much safer and effective anti-depressants available and if the sexual side effects are what concern you, try wellbutrin along with prozac (same as sarafem) as it can usually combat those side effects. Answered by Shery Lecompte 2 years ago.


Serzone(nefazodone) or prozac is better?
i have to start anti depressant which works more both of them can any body tell me Asked by Brandie Hughston 2 years ago.

Serzone is better and here is why: It works on two brain chemicals rather than only one like Prozac Nefazodone's claimed advantages over other antidepressants include reduced possibility of disturbed sleep or sexual dysfunction, and ability to treat some patients who did not respond to other antidepressant drugs. Answered by Reynalda Heuangvilay 2 years ago.


Who used to take the antidepressant Serzone that they took off the market? What medicine are you using now?
I took Serzone for a couple years in the 90s & it helped. I need a medication similiar to it. I cannot tolerate Zoloft or Paxil. Asked by Maryann Vasallo 2 years ago.

The company that made the "brand" named "Serzone" stopped making it. It was not taken off the market. There is a company named, TEVA, that still makes and sells nefazadone, which is the medicine that Serzone is the brand of. I know because I've taken that medication for years and still take it. Hope that helps. Answered by Lashay Vanderweerd 2 years ago.

Never took Serzone...Am on no medication for depression at present...All drugs legal or otherwise do is "mask the real problem"...Get busy, try doing for others, that will knock the "oh poor me" right out of you fast & there are no ugly side effects! Answered by Kyla Delacueva 2 years ago.

I heard Effexor works wonders & helps with weight loss! you could use as low as a 37.5 mg dose Answered by Joaquin Tavares 2 years ago.

I did, messed with my head. Now I take Cymbalta works great. Answered by Deb Arnaud 2 years ago.


Can Serzone be combined with Cymbalta?
My doc was looking into this when his computer went down. The cymbalta is best for pain, but the Serzone is best for depression for me. I really want to take them together. Serzone=Nefazadone Asked by Yoshiko Neglio 2 years ago.

duloxetine (cymbalta) and nefazadone (serzone) should NEVER be mixed. infact duloxetine should NEVER be mixed with any anti-depressants! the combined effects on the chemicals produced by the brain is catastrophic! it can cause permanent liver damage and increase risk of suicide. DO NOT TAKE THESE MEDS TOGETHER. consult your MD about other options, preferably a different one then prescribed you these drugs together in the fist place. good luck Answered by Quinn Saloom 2 years ago.


SerZone (nefazodone)?
Hi there,I have been wanting to titrate off nefazodone for years. Does anyone have experience with the withdrawal from this medication?I have been taking 600 mg (divided doses) q day.What can I expect? Any known cases of death from withdrawal?Is it better to do it on an impatient basis?I took it for... Asked by Malvina Shuffler 2 years ago.

Hi there, I have been wanting to titrate off nefazodone for years. Does anyone have experience with the withdrawal from this medication? I have been taking 600 mg (divided doses) q day. What can I expect? Any known cases of death from withdrawal? Is it better to do it on an impatient basis? I took it for severe panic attacks. I am worried that the attacks will return BIGTIME. Any and all information will be helpful. Thanks, Christine Answered by Verline Hickingbotham 2 years ago.

I do not know that medecine, but I went cold turkey on mine (paraxotine), and that was a terrible mistake. I felt so bad for long time after and was too stubborn to go back on. Whatever meds you're on, you should NOT stop/reduce them without doctor's advice! for your own sake! Answered by Demetra Cordes 2 years ago.

I have been taking Serzone for many years and am currently titrating off this drug. The process should take about six months with a 50 mg decrease every 6-8 weeks. I am experiencing some anxiety but it is manageable. Please don't try to go off without titration. JHM Answered by Rheba Felde 2 years ago.


Has anyone ever taken serzone and/or cymblata?
I have been on Serzone for 7 years and just started having severe side effects and my doctor is weaning me off and starting me on cymbalta. Getting off the serzone is HELL!!!! Just wanted to know if anyone has had a similar instance.....and does Cymbalta work for anyone? Asked by Darrell Jarry 2 years ago.

Yes I am on cymbalta! I've been on it 6 months. I have no side effects from it. It has helped me out. I was put on it for chronic pain. I still have pain but not like I used too. It has been a big relief to not have so much pain in my body and joints. Hugs! Answered by Euna Gradley 2 years ago.

Tried the cymbalta, didnt like the side effects and stopped after 6 weeks. I thought it helped a little, very little but not worth taking for a long time. I heard it was hard to get off of it. Answered by Wanda Schrecker 2 years ago.

I am taking Cymbalta and it has worked well for me. It's like Serzone as far as getting off of it, but I haven't suffered any side effects from it. I'd suggest that you try it. Answered by Stephane Altonen 2 years ago.

I ended up in the hospital becasue of the side effects of Cymbalta.. BUT.. not everyone has the same side effects from every med Everyone is unique Answered by Tammy Pacella 2 years ago.


Can nefazodone (Serzone) be taken while a woman is pregnant?
Asked by Garland Hesters 2 years ago.

It´s not advised to take it during pregnancy. It might cause a miscarriage or deformities. I would discuss this issue with a doctor not on yahoo answers !!! Answered by Lanelle Ikemoto 2 years ago.

Would definitely talk to your doctor about this as birth defects and malformities are highly probable Answered by Gussie Hauss 2 years ago.

No! You should seek advice from your OBGYN. Answered by Maryjane Minzenberger 2 years ago.


Has anyone heard of serzone?
I was just reading that it is better for people to take than sarafem. It also has no sexual side effects. Asked by Hanh Colvard 2 years ago.

Frequently Asked Questions What is nefazodone (Serzone)? Nefazodone (Serzone) is a new antidepressant with a chemical structure that is somewhat similar to that of the phenylpiperazine antidepressant, trazodone (Desyrel). The antidepressant action of nefazodone is thought to be dependent on its ability to block postsynaptic serotonin type-2 receptors and inhibit presynaptic serotonin reuptake. Nefazodone also blocks norepinephrine reuptake. Nefazodone does not have a chemical structure similar to the SSRIs, tricyclic antidepressants, monoamine oxidase inhibitors, bupropion, or venlafaxine. How does nefazodone differ from other antidepressants? One possibly important way in which nefazodone differs from other SSRIs is that while use of SSRIs is often associated with sexual dysfunction and sleep disturbances, these side-effects have been reported infrequently in people taking nefazodone. What kinds of depression can be treated with nefazodone? While the pre-marketing studies were restricted to patients with a DSM-III-R diagnosis of non-melancholic Major Depressive Disorder, it is expected that nefazodone will be prescribed for patients with Dysthymia, Major Depression, and Bipolar Disorder. Although nefazodone has mostly been studied for periods of administration of up to 8 weeks, it is expected that patients with long-standing depressions will take the drug for longer periods of time. Data on about 250 patients who took nefazodone for 12 or more months did not reveal any problems with administration for that length of time. As yet, there is no data on the effectiveness of nefazodone when used to treat patients whose depressions were so severe as to make hospitalization necessary. What are the side-effects of nefazodone? The side-effects that occurred significantly more commonly in people taking nefazodone as compared to placebo are: Side-effect Patients Dry mouth 25% Sleepiness/sedation 25% Nausea 22% Dizziness 17% Visual problems 16% Weakness 11% Lightheadedness 10% Confusion 7% Orthostatic hypotension 5% Note: The Psychopharmacology Forum of InterPsych has received one report of inappropriate erections in a patient taking nefazodone. It is expected that priapism will be reported shortly as inappropriate erections and priapism are often associated. Which side-effects force people to stop taking nefazodone? In the premarketing studies 16% of the 3496 depressed patients taking nefazodone discontinued the medication because of side-effects. The side-effects that the patients cited as the reason they dropped out that were mentioned at least twice as often for nefazodone as compared to placebo are: Side-effect Patients Nausea 3.5% Dizziness 1.9% Insomnia 1.5% Weakness 1.3% Agitation 1.2% Are there any special hazards for people with bipolar disorder? As with other antidepressants, people with bipolar disorder who are not being treated with a mood regulator such as lithium, valproate (Depakote), or carbamazepine (Tegretol) may be pushed into a manic episode when treated with nefazodone. In the pre-marketing studies, the rate of manic episodes in patients with bipolar disorder was 1.6%. Does nefazodone interact with other medications? Nefazodone increases the blood level of Seldane and Hismanal to possibly life-threatening levels. These antihistamines should never be taken while taking nefazodone. The blood levels of Halcion and Xanax are also increased by nefazodone. If Halcion is taken with nefazodone, its dose should be reduced by 75%. A reduction of 50% in the dose of Xanax is suggested if it is taken with nefazodone. Does nefazodone interact with alcohol? Although nefazodone has not been found to increase the impairment of cognitive or motor skills caused by alcohol, the manufacturer warns against drinking while taking nefazodone. Is nefazodone safe for a woman who is pregnant, about to become pregnant, or nursing an infant? There is no data to establish the safety of nefazodone for the fetus or nursing infant. Is nefazodone a satisfactory antidepressant for children and adolescents? Although there have been no published studies on the use of nefazodone for the treatment of children and adolescents with depression, it is expected that the drug will be prescribed for depressed children and adolescents. Is nefazodone a satisfactory antidepressant for the elderly? No special problems were encountered when nefazodone was studied in a group of 500 people over the age of 65 with depression. As with most drugs, when administered to the elderly, it is useful to start low and go slow. How is treatment with nefazodone initiated? Most psychiatrists start people with depression on 50 mg of nefazodone twice a day. At intervals of about one week, the dose can be increased by 100 mg per day. When nefazodone first was released the usual starting dose for adults was 100 mg twice a day. As many people found this dose to be too high, it has been replaced by a lower initial dose. When nefazodone is given to elderly patients the starting dose is usually 50 mg twice a day. What is the usual final dose of nefazodone? While doses up to 600 mg per day are approved by the FDA, some severely depressed patients have been treated with higher doses. Most depressed people respond to doses under 600 mg per day. How long does it take nefazodone to relieve depression? While most people taking nefazodone become aware of some lessening of depression within two to four weeks, there are some who experience relief within the first week and others who only experience relief after many weeks of therapy. Are there withdrawal effects if nefazodone is suddenly discontinued? A withdrawal syndrome following the abrupt discontinuation of nefazodone has not been described. Because the half-lives of nefazodone and its active metabolites are 18 hours or less, it is prudent to taper nefazodone rather than abruptly discontinue it. Is nefazodone toxic if an overdose is taken? Seven overdoses of nefazodone have been reported. The highest reported overdose was 11,200 mg. In some cases nefazodone was taken along with alcohol and/or other medications. All seven people who took an overdose recovered. What precautions are necessary when switching between nefazodone and an MAO inhibitor? When switching from an MAO inhibitor to nefazodone, there should be a 14-day interval between the discontinuation of the MAOI and the initiation of nefazodone therapy. When switching from nefazodone to an MAOI, a 7-day interval is adequate, because of nefazodone's short half-life. What does nefazodone cost? Nefazodone is supplied in tablets ranging from 100 mg to 250 mg in strength. The 100 mg tablets cost pharmacies nearly as much as the 250 mg tablets. It is expected that all strengths of nefazodone will be sold for between $0.80 and $1.25 per tablet. Might nefazodone be effective when a person has not responded to other antidepressants? Although there is no data on this, it is expected that some individuals who have failed to be helped by other antidepressants will be helped by nefazodone. What are the advantages of nefazodone? The low incidence of sexual side-effects and disturbed sleep are possible advantages of nefazodone. Has nefazodone been available in other countries? What do psychopharmacologists from those countries think of the drug? Nefazodone has been available in Canada for over six months. Most of the psychopharmacologists to whom I have spoken think that it is less effective than the SSRIs, and some have stopped writing prescriptions for it. Most of the nefazodone being prescribed in Canada is prescribed by nonpsychiatric physicians, not by psychiatrists. What did the Medical Letter conclude about nefazodone? The Medical Letter [1995, 37 (946), 33-35] concluded its review of nefazodone with the words: "Available data are inadequate to determine how nefazodone compares Answered by Jenette Alpert 2 years ago.

The most important thing to know here is that this drug was pulled off the market in Canada in 2003 and pulled from the US market in 2004 (although the generic form is still available-nefazadone) due to deaths resulting from liver failure directly associated with the drug. The significant danger, despite this side effect being rare, is that it is unpredictable and happens without warning, necessitating a liver transplant. There are much safer and effective anti-depressants available and if the sexual side effects are what concern you, try wellbutrin along with prozac (same as sarafem) as it can usually combat those side effects. Answered by Jonell Gazdik 2 years ago.

Depression is everywhere, some brains are just wired better to cope. This is why all of the drug companies are formulating anti-depressants. My sister in law, my husband's co-worker, my mother, my grandfather, my best friends mother (who ended up going back to school and getting her doctorate in psychology to help others with depression) - all had different paths to try and deal with this. None were short. At least today it's acceptable as a legitimate illness and not looked down upon. This is why Brooke Shields wrote a book on post partum depression. There are a gazillion medications, some take awhile to work, sometimes you need a change. Please don't finish the job. If things aren't changing then you need to change your counselor, doctor and perhaps meds. Some meds can cause depression and suicidal thoughts to increase - which is why the warning labels always say to call your doc immediately if you have these thoughts. Don't feel guilty about leaving your counselor to go to another. A diploma on the wall doesn't mean they graduated with all "A's"! Are you working? If not you need to fill your time with something productive that makes you feel worthwhile. If you come really close to finishing the job, call your local crisis hotline, go to the ER. It would be best if you are not alone during this time of stabilizing on the meds. And if your insurance covers it, there is absolutely not shame in asking to be admitted to an inpatient unit where they can monitor you and your meds. My grandfather and best friends mom both went the inpatient route, as did my husband's co-worker. My sister in law had daily intensive therapy and 2 or 3 medication changes and my mother had therapy several times a week along with medication. It can be conquered! Answered by Morris Flander 2 years ago.

Sarafem, the other drug you mention, is Prozac. It's been marketed under the name Sarafem in the US for women who have severe PMS but who might not want an antidepressant - bit of a crafty marketing ploy, and bit deceptive... Answered by Sam Colletti 2 years ago.

My husband took it for about 6 months. He had a lot of weight gain so he quit. He now takes Lamictal with no side effects whatsoever. Best wishes! Answered by Waylon Bery 2 years ago.

Serzone was an antidepressant that I took. It was taken off the market a few years ago in the U.S. when a few people in Europe died from liver failure. It worked very good for me. Answered by Aracelis Ferlenda 2 years ago.

Yes, it is an antidepressant medication. What would you like to know about it specifically? Answered by Thad Shike 2 years ago.

i have never heard of it. is it some kind of sickness or something??? Answered by Jacqueline Costello 2 years ago.

ummmmmmm no i have no idea Answered by Errol Snedden 2 years ago.


Anyone familiar with Ativan? How about Serzone?
I took Serzone for about 6 years and through a series of insurance problems, ended up off the Serzone and on Ativan. I've been taking "about" 2 mg. of Ativan a day for the last 1 1/2 years. ( 1/2 mg 3 times a day - 4 times max)Anyway, I made an attempt at cutting down on the Ativan yesterday by... Asked by Suzette Berno 2 years ago.

I took Serzone for about 6 years and through a series of insurance problems, ended up off the Serzone and on Ativan. I've been taking "about" 2 mg. of Ativan a day for the last 1 1/2 years. ( 1/2 mg 3 times a day - 4 times max) Anyway, I made an attempt at cutting down on the Ativan yesterday by not taking a dose at bedtime. I woke up this morning about 3 am and just sort of layed in bed. When I got up around 6 am, I felt very strange. I just felt like crying. And I did. I took 1/2 mg dose and by 7 am I felt much better. Question: Is getting off the Ativan going to be a really bad experience? I don't want to go off my nut but I'd really like to cut the dose back. Could starting the Serzone again make it easier? Emails are welcome. Just go to my profile to email me. Thanks. Answered by Nicky Minto 2 years ago.


Has anyone tried Serzone (Nefazodone)?
I was really looking for someone who has tried this stuff, thanks for the info though. I am aware that it can cause fatal liver failure. Asked by Anisa Manus 2 years ago.

I took Serzone for 3 years. I worked great. I was not able to handle the side affects of the other designer drugs like prozac or zoloft...etc. I took 2 mg of colonapin at Night for sleep and the combo worked great. My Dr. had me take a simple liver function test every six months because the med was causing some problems with liver damage (including statistically significant deaths) I stopped taking the med after I lost my health insurance. No other Dr. will per scribe it now because it is on th e"black list" I would still take it as long as I took the liver function tests periodically. Good Luck Answered by Izola Rundell 2 years ago.

Serzone sucks Answered by Nickie Mcmorrow 2 years ago.


Has anyone heard of serzone?
Asked by Faviola Vidro 2 years ago.

What is Serzone? • Serzone is an antidepressant medication. It affects chemicals in the brain that may become unbalanced and cause depression. • Serzone is used to relieve symptoms of depression such as feelings of sadness, worthlessness, or guilt; loss of interest in daily activities; changes in appetite; tiredness; sleeping too much; insomnia; and thoughts of death or suicide. Answered by Angel Monds 2 years ago.

The most important thing to know here is that this drug was pulled off the market in Canada in 2003 and pulled from the US market in 2004 (although the generic form is still available-nefazadone) due to deaths resulting from liver failure directly associated with the drug. The significant danger, despite this side effect being rare, is that it is unpredictable and happens without warning, necessitating a liver transplant. There are much safer and effective anti-depressants available and if the sexual side effects are what concern you, try wellbutrin along with prozac (same as sarafem) as it can usually combat those side effects. Answered by Jovita Livinton 2 years ago.


Serzone(nefazodone) or prozac is better?
i have to start anti depressant which works more both of them can any body tell me Asked by Heriberto Mincks 2 years ago.

Serzone is better and here is why: It works on two brain chemicals rather than only one like Prozac Nefazodone's claimed advantages over other antidepressants include reduced possibility of disturbed sleep or sexual dysfunction, and ability to treat some patients who did not respond to other antidepressant drugs. Answered by Latonya Dorsainvil 2 years ago.


Who used to take the antidepressant Serzone that they took off the market? What medicine are you using now?
I took Serzone for a couple years in the 90s & it helped. I need a medication similiar to it. I cannot tolerate Zoloft or Paxil. Asked by Emma Heidelburg 2 years ago.

The company that made the "brand" named "Serzone" stopped making it. It was not taken off the market. There is a company named, TEVA, that still makes and sells nefazadone, which is the medicine that Serzone is the brand of. I know because I've taken that medication for years and still take it. Hope that helps. Answered by Luz Gerrard 2 years ago.

Never took Serzone...Am on no medication for depression at present...All drugs legal or otherwise do is "mask the real problem"...Get busy, try doing for others, that will knock the "oh poor me" right out of you fast & there are no ugly side effects! Answered by Shaun Delzer 2 years ago.

I heard Effexor works wonders & helps with weight loss! you could use as low as a 37.5 mg dose Answered by Jacquie Morphy 2 years ago.

I did, messed with my head. Now I take Cymbalta works great. Answered by Edgardo Goldfischer 2 years ago.


Can Serzone be combined with Cymbalta?
My doc was looking into this when his computer went down. The cymbalta is best for pain, but the Serzone is best for depression for me. I really want to take them together. Serzone=Nefazadone Asked by Randy Tewa 2 years ago.

duloxetine (cymbalta) and nefazadone (serzone) should NEVER be mixed. infact duloxetine should NEVER be mixed with any anti-depressants! the combined effects on the chemicals produced by the brain is catastrophic! it can cause permanent liver damage and increase risk of suicide. DO NOT TAKE THESE MEDS TOGETHER. consult your MD about other options, preferably a different one then prescribed you these drugs together in the fist place. good luck Answered by Hung Intrieri 2 years ago.


SerZone (nefazodone)?
Hi there,I have been wanting to titrate off nefazodone for years. Does anyone have experience with the withdrawal from this medication?I have been taking 600 mg (divided doses) q day.What can I expect? Any known cases of death from withdrawal?Is it better to do it on an impatient basis?I took it for... Asked by Velda Raudenbush 2 years ago.

Hi there, I have been wanting to titrate off nefazodone for years. Does anyone have experience with the withdrawal from this medication? I have been taking 600 mg (divided doses) q day. What can I expect? Any known cases of death from withdrawal? Is it better to do it on an impatient basis? I took it for severe panic attacks. I am worried that the attacks will return BIGTIME. Any and all information will be helpful. Thanks, Christine Answered by Von Debreto 2 years ago.

I do not know that medecine, but I went cold turkey on mine (paraxotine), and that was a terrible mistake. I felt so bad for long time after and was too stubborn to go back on. Whatever meds you're on, you should NOT stop/reduce them without doctor's advice! for your own sake! Answered by Geralyn Ringo 2 years ago.

I have been taking Serzone for many years and am currently titrating off this drug. The process should take about six months with a 50 mg decrease every 6-8 weeks. I am experiencing some anxiety but it is manageable. Please don't try to go off without titration. JHM Answered by Leonia Bushard 2 years ago.


Has anyone ever taken serzone and/or cymblata?
I have been on Serzone for 7 years and just started having severe side effects and my doctor is weaning me off and starting me on cymbalta. Getting off the serzone is HELL!!!! Just wanted to know if anyone has had a similar instance.....and does Cymbalta work for anyone? Asked by Dori Verbeke 2 years ago.

Yes I am on cymbalta! I've been on it 6 months. I have no side effects from it. It has helped me out. I was put on it for chronic pain. I still have pain but not like I used too. It has been a big relief to not have so much pain in my body and joints. Hugs! Answered by Van Mccornack 2 years ago.

Tried the cymbalta, didnt like the side effects and stopped after 6 weeks. I thought it helped a little, very little but not worth taking for a long time. I heard it was hard to get off of it. Answered by Aleisha Zagel 2 years ago.

I am taking Cymbalta and it has worked well for me. It's like Serzone as far as getting off of it, but I haven't suffered any side effects from it. I'd suggest that you try it. Answered by Shawanda Edgman 2 years ago.

I ended up in the hospital becasue of the side effects of Cymbalta.. BUT.. not everyone has the same side effects from every med Everyone is unique Answered by Elayne Mackinaw 2 years ago.


Can nefazodone (Serzone) be taken while a woman is pregnant?
Asked by Gearldine Mcillwain 2 years ago.

It´s not advised to take it during pregnancy. It might cause a miscarriage or deformities. I would discuss this issue with a doctor not on yahoo answers !!! Answered by Shaunda Politz 2 years ago.

Would definitely talk to your doctor about this as birth defects and malformities are highly probable Answered by Wenona Paoli 2 years ago.

No! You should seek advice from your OBGYN. Answered by Andera Angotti 2 years ago.


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